Recent Advances in Interventional Fluorescence Imaging: Toward the Precise Visualization of Transarterial Mini-Invasive Delivery Systems  

作　　者：Xiaoxiao Shi Dazhuang Xu Hongwei Cheng Chengchao Chu Gang Liu 

机构地区：[1]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361102,China

出　　处：《Accounts of Materials Research》2023年第3期251-263,共13页材料研究述评（英文）

基　　金：supported by the Major State Basic Research Development Program of China(2017YFA0205201);the National Natural Science Foundation of China(81925019,81422023,and U1705281);the Fundamental Research Funds for the Central Universities(20720190088,20720200019,and 2020Y4003);the Program for New Century Excellent Talents in University,China(NCET-13-0502).

摘　　要：CONSPECTUS:Interventional fluorescence imaging has gradually developed into a promising imaging strategy for the diagnosis of diseases in clinic.This strategy could benefit interventional targeted treatment because of the clear display of microstructures at the margins and boundaries.There are some stranded crucial issues in clinical application:(i)fast clearance of fluorescence probes;(ii)light instability and photobleaching;and(iii)residual and microsatellite lesions.The development of superstable homoge-neous intermixed formulation technology(SHIFT)can solve the aforementioned clinical problems for precision hepatectomy.Interventional fluorescence imaging based on SHIFT-prepared product has some advantages such as(i)strong stability,(ii)greatly extending imageable time window,and(iii)precisely visualizing microsatellite lesions.In this Account,we overview our current progress in interventional fluorescence imaging based on SHIFT method for surgical resection following long-lasting embolization conversion.To greatly realize interventional fluorescence imaging,we summarize clinical and preclinical application of interventional fluorescence imaging in a transarterial delivery system.Indeed,compared with conventional fluorescence imaging,interventional fluorescence imaging possesses non-negligible strengths on improved intensity in target location and step-down systemic toxicity.Unfortunately,a challenging issue is that immobile fluorescence performance is difficult to maintain after long-time embolization,resulting in a failed hepatectomy.On this basis,associated with our previous research,SHIFT was proposed and developed.Thus,we detailedly introduce and account the development and preponderance of SHIFT on interventional fluorescence imaging.Predictably,after lengthy embolization,its lightful fluorescence was still observable in tumor targets of a clinical trial.To regulate the fluorescence rendering of microsatellite lesion,SHIFT combining with pure nanoprobes(nanoICG)occurs,namely SHIFT nanoICG,and we dwell on

关 键 词：FORMULATION RENDERING MAINTAIN 

分 类 号：R318[医药卫生—生物医学工程]