Lanthanide-Doped Inorganic Nanoprobes for Luminescent Assays of Biomarkers  

作　　者：Luping Wang Siyuan Han Chenliang Li Datao Tu Xueyuan Chen 

机构地区：[1]不详

出　　处：《Accounts of Materials Research》2023年第2期193-204,共12页材料研究述评（英文）

基　　金：supported by the National Key R&D Program of China(No.2022YFB3503700);the National Natural Science Foundation of China(Nos.21975257,22275188,22135008,U22A20398);the CAS/SAFEA International Partnership Program for Creative Research Teams,Natural Science Foundation of Fujian Province(No.2021L3024).

摘　　要：Tremendous progress in nanomaterial and nanotechnology has been made in recent years,which greatly contributes to the development of inorganic nanoparticles(NPs)as luminescent probes in diverse biomedical applications.In particular,these luminescent nanoprobes are widely employed for sensitive assays of biomarkers like disease markers.Generally,the luminescent bioassay technologies mainly rely on conventional molecular probes such as lanthanide(Ln3+)chelates or organic dyes,which suffer from inferior photochemical stability,low photobleaching,potential long-term toxicity,or high background noise.In contrast,Ln3+-doped NPs possess distinct physicochemical properties including better photostability,lower toxicity,and superior optical properties like long photoluminescent(PL)lifetime,narrow emission band,and tunable spectral range from the ultraviolet to the second near-infrared(NIR-II),which make them extremely ideal as luminescent nanoprobes.As such,enormous research enthusiasm has been invested in this fascinating field of Ln3+-doped luminescent nanoprobes in recent years.Accordingly,background-free luminescent bioassays with high signal-to-noise have been achieved by employing Ln3+-doped NPs on the basis of their downshifting luminescence(DSL)with a long PL lifetime,NIR-II luminescence with long-wavelength emissions,or upconverting luminescence(UCL)upon NIR excitation.However,there are still key challenges for Ln3+-doped nanoprobes owing to their low brightness and quantum yield,which restrict their biomedical applications.During the past decade,we have explored efficient approaches for the synthesis and design of highly efficient Ln3+-doped nanoprobes toward ultrasensitive luminescent bioassay of disease markers.In this Account,we summarize our most recent endeavors toward the development of inorganic Ln3+-doped NPs as sensitive nanoprobes for luminescent bioassays.First,we overview the approaches of controlled synthesis and optical manipulation to obtain highly efficient Ln3+-doped NPs with desirable optical p

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分 类 号：TB383[一般工业技术—材料科学与工程]