眼部类器官的研究进展  

Research progress of ocular organoids

在线阅读下载全文

作  者:李梦旋 张昊坤 颜华[1] Mengxuan Li;Haokun Zhang;Hua Yan(Department of Ophthalmology,Tianjin Medical University General Hospital,Tianjin Key Laboratory of Ocular Trauma,Tianjin 300052,China)

机构地区:[1]天津医科大学总医院眼科、天津市眼外伤研究与转化重点实验室,天津300052

出  处:《中华眼科杂志》2023年第7期587-593,共7页Chinese Journal of Ophthalmology

摘  要:眼部类器官是当前广泛开展的与眼科基础和临床相关的一项研究,其目的是真实地模拟人眼的组织结构和功能,以便为相关疾病的机制和干预研究提供模型基础。在眼科基础研究,体外真实模拟人眼的组织结构及功能长久以来都是一项挑战,许多研究尝试改进人眼体外模型,以期更有效地用于研究疾病致病机制以及药物应用效果。随着科技进步,人眼的局部组织如角膜、视网膜等也实现了在体外单独构建。本文就眼部(尤其是角膜和视网膜)类器官的最新研究进展进行综述。The development of ocular organoids,which closely mimic the tissue structure and functionality of the human eye,has emerged as a prominent area of research in the field of ophthalmology.These organoids serve as valuable models for investigating the mechanisms and interventions of eye-related diseases.However,the establishment of in vitro models that accurately represent the tissue structure and functionality of the human eye has long been a challenge in ophthalmic research.Numerous efforts have been made to enhance the fidelity of ocular organoid models,aiming to improve their suitability for studying disease pathogenesis and drug efficacy.With advancements in technology,it has become possible to construct individual components of the eye,such as the cornea and retina,in vitro.This review summarizes the recent advancements in ocular organoid research,with a focus on corneal and retinal organoids.

关 键 词:类器官  角膜 视网膜 

分 类 号:R318[医药卫生—生物医学工程]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象