强脉冲光联合超脉冲点阵CO_(2)激光治疗面部痤疮瘢痕的疗效及相关皮肤生理指标分析  

Effects of Intense Pulsed Light Combined with Ultra-pulsed Fractional CO_(2) Laser on Facial Acne Scar and Analysis of Related Skin Physiological Indexes

作　　者：刘荣奇[1] 张会娜 范斌 曹洋[1] LIU Rongqi;ZHANG Huina;FAN Bin;CAO Yang(Department of Dermatology,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;Beijing Institute of Traditional Chinese Medicine,Beijing 100700,China)

机构地区：[1]首都医科大学附属北京中医医院皮肤科,北京100010 [2]北京市中医药研究所,北京100700

出　　处：《中国美容医学》2023年第7期98-102,共5页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨强脉冲光联合超脉冲点阵CO_(2)激光治疗面部痤疮瘢痕的效果及对皮肤生理指标的影响。方法:回顾性分析64例面部痤疮瘢痕患者的资料,依照接受治疗方案不同分为两组,即采用超脉冲点阵CO_(2)激光治疗的患者为对照组,选择超脉冲点阵CO_(2)激光联合强脉冲光治疗纳入观察组,并通过二元Logistic回归分析构建倾向性得分模型(卡钳值为0.5),经倾向性匹配评分评估共得出32组基线差异无统计学意义的病例资料。评定两组治疗5次后的临床疗效,对比两组治疗前后的瘢痕面积程度、痤疮瘢痕严重程度[临床痤疮瘢痕评估量表(ECCA)权重评分]、皮肤生理指标[VISIA皮肤分析仪中紫外线、红色区、紫质、皱纹、斑点、纹理、毛孔及棕色斑共8项评分],记录两组治疗期间出现的不良反应。结果:观察组的临床总有效率显著高于对照组(93.75%VS 71.88%,P<0.05);治疗5次后,两组瘢痕面积较治疗前均显著缩小(P<0.05),两组ECCA权重评分、VISIA皮肤分析仪8项指标(紫外线、红色区、紫质、皱纹、斑点、纹理、毛孔及棕色斑)评分较治疗前降低(P<0.05),且观察组除VISIA评分中斑点、棕色斑2项评分之外其余上述指标均低于对照组,差异具有统计学意义(P<0.05);观察组不良反应总发生率低于对照组(9.38%VS31.25%,P<0.05)。结论:强脉冲光联合超脉冲点阵CO_(2)激光治疗面部痤疮瘢痕的疗效显著,能明显缩小痤疮瘢痕面积,减轻痤疮瘢痕严重程度,并有效改善皮肤生理状况,减少治疗不良反应,临床应用安全、有效。Objective To explore the effects of intense pulsed light combined with ultra-pulsed fractional CO_(2) laser on facial acne scar and its influence on skin physiological indexes.Methods The data of 64 patients with facial acne scars were retrospectively analyzed and the patients were divided into two groups according to different treatment regimens.The patients treated with ultra-pulsed fractional CO2 laser were selected as the control group,and the patients with ultra-pulsed fractional CO_(2) laser combined with intense pulsed light treatment were included in the observation group.Binary logistic regression analysis was used to construct the propensity score model(caliper value=0.5).32 pairs of case data without statistical baseline differences were obtained by propensity score matching evaluation.The clinical efficacy of the two groups after 5 times of treatment was evaluated,and the scar area,severity of acne scar[ECCA weighting score]and skin physiological indexes[ultraviolet,red zone,porphyria,wrinkles,spots,texture,pores and brown spots in VISIA skin analyzer]were compared between the two groups before and after treatment.Adverse reactions were recorded in both groups during treatment.Results The total clinical effective rate in the observation group was significantly higher than that in the control group(93.75%VS 71.88%,P<0.05).After 5 times of treatments,the scar area in the two groups was significantly reduced compared with that before treatment(P<0.05),and the ECCA weighting score,scores of eight indexes in VISIA skin analyzer(ultraviolet,red zone,porphyria,wrinkles,spots,texture,pores and brown spots)were decreased in the two groups compared with those before treatment(P<0.05),and the above scores except for VISIA spots and brown spots in the observation group were lower than those in the control group(P<0.05).The total incidence rate of adverse reactions in the observation group was lower than that in the control group(9.38%VS 31.25%,P<0.05).Conclusion Intense pulsed light combined with ultra-pulsed fra

关 键 词：强脉冲光 超脉冲点阵CO_(2)激光 面部痤疮瘢痕 皮肤生理指标 

分 类 号：R619.6[医药卫生—外科学]