单频准分子激光联合甲氨蝶呤治疗斑块型银屑病的疗效及对患者炎性因子、DLQI指数、PASI指数的影响  

Effects of monochromatic excimer laser combined with methotrexate on inflammatory factors, DLQI, and PASI in patients with plaque psoriasis

作　　者：罗茜 王亚莎[1] 黄俊萍[1] 陈蕾 张敏 LUO Xi;WANG Ya-sha;HUANG Jun-ping;CHEN Lei;ZHANG Min(Department of Dermatology,Ankang Hospital of Traditional Chinese Medicine,Ankang 725000,Shaanxi,CHINA)

机构地区：[1]安康市中医医院皮肤科,陕西安康725000

出　　处：《海南医学》2023年第14期2037-2040,共4页Hainan Medical Journal

摘　　要：目的 评价单频准分子激光联合甲氨蝶呤治疗斑块型银屑病的疗效,并探讨其对患者炎性因子、皮肤病学生活质量(DLQI)指数、严重程度指数(PASI)指数的影响。方法 回顾性分析2020年1月至2022年5月安康市中医医院皮肤科收治的380例斑块型银屑病患者的临床诊治资料,根据治疗方案不同分为观察组(n=122)和对照组(n=258),对照组仅给予甲氨蝶呤治疗,观察组在对照组治疗的基础上给予单频准分子激光治疗,两组均连续治疗2周。比较两组患者的临床疗效以及治疗前后的炎性因子[肿瘤坏死因子-α (TNF-α)、白介素-6 (IL-6)和C反应蛋白(CRP)]、DLQI指数和PASI指数。结果 观察组患者的治疗总有效率为93.44%,明显高于对照组的77.90%,差异具有统计学意义(P<0.05);治疗前,两组患者的TNF-α、IL-6和hs-CRP水平比较差异均无统计学意义(P>0.05),治疗后,两组患者的炎症因子均下降,且观察组患者的TNF-α、IL-6和hs-CRP水平分别为(13.49±1.12) mg/L、(12.89±1.18) ng/L、(13.47±2.41) mg/L,明显低于对照组的(16.87±1.09) mg/L、(17.63±1.18) ng/L、(16.22±2.18) mg/L,差异均具有统计学意义(P<0.05);治疗前,两组患者的DLQI指数、PASI指数比较差异均无统计学意义(P>0.05),治疗后,两组患者的DLQI指数、PASI指数均下降,且观察组患者的DLQI指数、PASI指数分别为(4.49±1.12)分、(9.24±1.38)分,明显低于对照组的(7.24±1.09)分、(14.36±1.42)分,差异均具有统计学意义(P<0.05)。结论 单频准分子激光联合甲氨蝶呤治疗斑块型银屑病能够有效改善患者的炎性因子,降低DLQI和PASI指数,临床应用疗效较高。Objective To investigate effects of monochromatic excimer laser combined with methotrexate on inflammatory factors,Dermatology Life Quality Index(DLQI),and Psoriasis Area and Severity Index(PASI)scores in patients with plaque psoriasis.Methods The clinical data of 380 patients with plaque psoriasis in Department of Dermatology,Ankang Hospital of Traditional Chinese Medicine from January 2020 to May 2022 were retrospectively analyzed.Patients were classified into two groups according to different treatment methods:the control group(n=258)received methotrexate therapy,and the experimental group(n=122)received monochromatic excimer laser combined with methotrexate.Treatment in both groups lasted for 2 weeks.Then comparison was conducted on clinical efficacy rate,inflammation factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP)],DLQI,and PASI scores.Results The clinical efficacy rate was 93.44%in experimental group,which was significantly higher than 77.90%in the control group(P<0.05).Before treatment,the serum levels of TNF-α,IL-6,and hs-CRP showed no statistically significant difference between two groups(P>0.05).After treatment,the three inflammatory factors showed a decrease in both groups,and the levels were(13.49±1.12)mg/L,(12.89±1.18)ng/L,and(13.47±2.41)mg/L in the experimental group,which were significantly lower than(16.87±1.09)mg/L,(17.63±1.18)ng/L,and(16.22±2.18)mg/L in the control group(P<0.05).Baseline DLQI and PASI score showed no statistically significant difference between the two groups(P>0.05).After treatment,DLQI and PASI scores decreased in both groups,and the scores in the experimental group were(4.49±1.12)points and(9.24±1.38)points,which were significantly lower than(7.24±1.09)points and(14.36±1.42)points in the control group(P<0.05).Conclusion Application of monochromatic excimer laser combined with methotrexate therapy in the treatment of plaque psoriasis can effectively ameliorate the inflammatory factors,and reduce DLQI and PASI scores in patients,

关 键 词：斑块型银屑病 单频准分子激光 甲氨蝶呤 临床疗效 炎性因子 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]