新生儿Fc受体抑制剂在神经系统自身免疫性疾病治疗中的研究进展  

Advances in research of neonatal Fc receptor inhibitors in the treatment of autoimmune disease of the nervous system

作　　者：朱丽娜 唐窈 王赛 王格格 郭子燕 刘欣雨 郭梦凯 吴军[1] Zhu Lina;Tang Yao;Wang Sai;Wang Gege;Guo Ziyan;Liu Xinyu;Guo Mengkai;Wu Jun(Department of Neurology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院神经内科,郑州450052

出　　处：《中华神经科杂志》2023年第7期830-836,共7页Chinese Journal of Neurology

基　　金：国家自然科学基金(U1604181);河南省医学科技攻关计划联合共建项目(LHGJ20190078);河南省医学教育研究项目(Wjlx2020531);河南省重点研发与推广专项(科技攻关)(212102310834);河南省自然科学基金(232300420043)。

摘　　要：神经系统自身免疫性疾病是人体免疫系统攻击自身神经系统,从而造成相应组织结构破坏和功能损伤的一类疾病。大量的基础研究和长期的临床实践已证实,干预性地清除致病性自身抗体能够有效减轻免疫损伤、抑制病情进展、改善预后。新生儿Fc受体(FcRn)介导的IgG循环保护机制成就了IgG的长半衰期和血浆中的高水平。FcRn抑制剂能够靶向阻断FcRn与IgG的结合,加快IgG的清除,降低IgG水平。因此,将FcRn抑制剂用于治疗神经系统自身免疫性疾病,理论上有助于加快致病性IgG的清除、取得良好的临床疗效,应用前景可观。近年来这方面的研究已取得了较大的进展,文中将对此进行综述。Autoimmune diseases of the nervous system are a group of diseases caused by the body′s immune system attacking its own nervous system,resulting in structural damage and functional impairment of the corresponding tissues.Interventional clearance of pathogenic auto-antibodies has been shown to be effective in reducing immune damage,inhibiting disease progression and improving prognosis through extensive basic research and long-term clinical practice.The neonatal Fc receptor(FcRn)-mediated circulating protection mechanism of IgG contributes to the long half-life and high plasma levels of IgG.FcRn inhibitors are able to target and block the binding of FcRn to IgG,accelerating IgG clearance and reducing IgG levels.Therefore,the use of FcRn inhibitors in the treatment of autoimmune diseases of the nervous system could theoretically help to accelerate the clearance of pathogenic IgG,achieve good clinical efficacy and have promising applications.Research in this area has made considerable progress in recent years and this article will review this.

关 键 词：神经系统自身免疫疾病 免疫球蛋白G FcRn抑制剂 

分 类 号：R593.2[医药卫生—内科学]