MR定量磁化率成像联合三维动脉自旋标记序列对3个海拔地区健康志愿者脑氧代谢的研究  

Study on cerebral oxygen metabolism of healthy volunteers at three altitude areas by MR quantitative susceptibility mapping combined with three-dimensional arterial spin labeling sequence

作　　者：张永海[1] 杨林 张勇[3] 大旺堆 杨梅[1] 白峻虎[1] 李耀东 黄尚勇 孟庆宁 殷雅彦 Zhang Yonghai;Yang Lin;Zhang Yong;Dawangdui;Yang Mei;Bai Junhu;Li Yaodong;Huang Shangyong;Meng Qingning;Ya′yan Yin(Department of Imaging,Qinghai Provincial People′s Hospital,Xining 810000,China;Graduate School of Qinghai University,Xining 810000,China;Department of Imaging,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China;Department of Imaging,Lhasa People′s Hospital,Lhasa 850000,China;Department of Imaging,the Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China;Department of Imaging,the Fifth People′s Hospital of Qinghai Province,Xining 810000,China;Department of Imaging,Xuanwu Hospital,Capital Medical University,Peking University,Beijing 100032,China)

机构地区：[1]青海省人民医院影像科,西宁810000 [2]青海大学研究生院,西宁810000 [3]郑州大学第一附属医院影像科,郑州450000 [4]拉萨市人民医院影像科,拉萨850000 [5]福建医科大学附属第二医院影像科,泉州362000 [6]青海省第五人民医院影像科,西宁810000 [7]首都医科大学宣武医院影像科,北京100032

出　　处：《中华放射学杂志》2023年第7期748-755,共8页Chinese Journal of Radiology

基　　金：青海省基础研究计划(2018-ZJC-704)。

摘　　要：目的采用MR定量磁化率成像(QSM)联合三维动脉自旋标记(3D-ASL)探讨3个海拔地区健康志愿者的脑氧代谢的差异。方法收集2019年3月至2020年10月在郑州大学第一附属医院招募的郑州汉族志愿者,青海省第五人民医院招募的西宁汉族志愿者,拉萨市人民医院招募的拉萨汉族志愿者、藏族志愿者,并按照年龄分别分为21~30岁组、31~40岁组、41~50岁组。所有志愿者接受MR QSM联合3D-ASL序列成像,采集脑灰质、白质的氧摄取分数(OEF)及脑血流量(CBF)图像,获得OEF值及CBF值,并计算出脑氧代谢率(CMRO_(2))值。多组间各指标的比较采用单因素方差分析,两两比较采用LSD-t检验。结果共纳入132名志愿者,其中郑州汉族志愿者38名,21~30岁组9名、31~40岁组13名、41~50岁组16名;西宁汉族志愿者27名,其中21~30岁组9名、31~40岁组8名、41~50岁组10名;拉萨汉族志愿者34名,其中21~30岁组13名、31~40岁组11名、41~50岁组10名;拉萨藏族志愿者33名,其中21~30岁组10名、31~40岁组10名、41~50岁组13名。21~30岁组中,不同海拔地区志愿者间脑灰质OEF值总体差异有统计学意义(P<0.05),其中拉萨藏族与西宁汉族、拉萨汉族间OEF值差异均有统计学意义(P<0.05)。不同海拔地区志愿者间脑灰质CMRO_(2)值总体差异有统计学意义(P<0.05),其中拉萨藏族与郑州汉族、西宁汉族、拉萨汉族间CMRO_(2)值差异均有统计学意义(P<0.05)。31~40岁组中,不同海拔地区志愿者间脑灰质和白质CBF值总体差异均有统计学意义(P<0.05),其中郑州汉族与西宁汉族、拉萨汉族、拉萨藏族间脑灰质和白质CBF值差异均有统计学意义(P<0.05)。不同海拔地区志愿者间脑灰质和白质OEF值总体差异均有统计学意义(P<0.05),其中郑州汉族与西宁汉族、拉萨汉族间脑灰质和白质OEF值差异均有统计学意义(P<0.05),拉萨汉族与拉萨藏族间脑灰质和白质OEF值差异有统计学意义(P<0.05)。不同海拔�Objective To investigate the differences in cerebral oxygen metabolism in healthy volunteers at three altitude areas by MR quantitative magnetic susceptibility imaging(QSM)combined with three-dimensional arterial spin labeling(3D-ASL).Methods From March 2019 to October 2020,Zhengzhou Han Chinese volunteers recruited from the First Affiliated Hospital of Zhengzhou University,Xining Han Chinese volunteers recruited from the Fifth People′s Hospital of Qinghai Province,Lhasa Han Chinese volunteers and Tibetan volunteers recruited from Lhasa People′s Hospital were collected.They were divided into 21-30 age group,31-40 age group,and 41-50 age group.All the volunteers underwent MR QSM combined with 3D-ASL sequence imaging,and oxygen extraction fraction(OEF)and cerebral blood flow(CBF)images of gray matter,and white matter were collected,OEF and CBF values were obtained,and cerebral metabolic rate of oxygen(CMRO_(2))values were calculated.The comparison of various indicators among multiple groups was conducted using one-way ANOVA,and pairwise comparisons were conducted using LSD-t test.Results A total of 132 volunteers were included,including 38 Han Chinese volunteers in Zhengzhou,9 in the 21-30 age group,13 in the 31-40 age group and 16 in the 41-50 age group;27 Han Chinese volunteers in Xining,including 9 in the 21-30 age group,8 in the 31-40 age group and 10 in the 41-50 age group;34 Han Chinese volunteers in Lhasa,including 13 in the 21-30 age group,11 in the 31-40 age group and 10 in the 41-50 age group;and 33 Tibetan volunteers in Lhasa,including 10 in the 21-30 age group,10 in the 31-40 age group and 13 in the 41-50 age group.In the group aged 21-30 years,the overall difference in brain gray matter OEF values among volunteers from different altitudes was statistically significant(P<0.05),with statistically significant differences in OEF values between Tibetans in Lhasa and Han Chinese in Xining,Han Chinese in Lhasa(P<0.05).The overall difference in CMRO_(2) values in the gray matter of volunteers at different

关 键 词：高海拔 磁共振成像 脑氧代谢 

分 类 号：R445.2[医药卫生—影像医学与核医学]