喜树碱及其衍生物的聚乙二醇化学修饰药物研究进展  

Research Progress in Polyethylene Glycol Chemical Modification Drugs of Camptothecin and Its Derivatives

作　　者：焦喜悦 雷建都[1] 朱礼玉 朱华泰 张志成 何静[1] Jiao Xiyue;Lei Jiandu;Zhu Liyu;Zhu Huatai;Zhang Zhicheng;He Jing(College of Materials Science and Technology,Beijing Forestry University,Beijing,100083)

机构地区：[1]北京林业大学材料科学与技术学院,北京100083

出　　处：《化学通报》2023年第7期844-852,843,共10页Chemistry

基　　金：国家重点研发计划项目(2019YFB1309703);北京市自然科学基金项目(2202034)资助。

摘　　要：喜树碱及其衍生物药物是一类重要的抗肿瘤药物,但其存在水溶性差、生物利用度低、毒副作用大等问题,喜树碱及其衍生物的聚乙二醇化学修饰具有十分诱人的前景,但目前国内研究较少,本文综述了喜树碱及其衍生物的聚乙二醇化学修饰药物的研究进展与临床研究报道,为发掘结构明确、组成稳定的新型化学修饰药物提供理论基础和技术支撑。As important antitumor drugs,camptothecin and its derivatives are limited in further application due to several problems such as poor water solubility,low bioavailability,and high toxic side effects.Based on these drawbacks,chemical modification using polyethylene glycol(PEG)has become an effective way to show great promise and significance,and there are few related studies in domestic.This paper reviews the research progress and clinical study reports on PEG modification of camptothecin and its derivatives,providing theoretical basis and technical support for the discovery of novel chemically modified drugs with clear structures and stable compositions.

关 键 词：喜树碱 伊立替康 7-乙基-10-羟基喜树碱 聚乙二醇 PEG-CPT 

分 类 号：TQ460.1[化学工程—制药化工]