卵胞质内单精子注射技术有效性及其对子代安全性影响的研究进展  

Research progress on the effectiveness and offspring safety of intracytoplasmic sperm injection technology

作　　者：张楠[1] 田甜 杨蕊[1] Zhang Nan;Tian Tian;Yang Rui(Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,National Clinical Research Center for Obstetrics and Gynecology,Key Laboratory of Assisted Reproduction,Ministry of Education,Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology,Beijing 100191,China)

机构地区：[1]北京大学第三医院妇产科生殖医学中心、国家妇产疾病临床医学研究中心、辅助生殖教育部重点实验室、北京市生殖内分泌与辅助生殖技术重点实验室,北京100191

出　　处：《中华生殖与避孕杂志》2023年第6期588-593,共6页Chinese Journal of Reproduction and Contraception

基　　金：北京市科技计划(Z191100006619085、Z191100006619076);国家自然科学基金(82171632);国家重点研发计划(2021YFC2700605)。

摘　　要：卵胞质内单精子注射(intracytoplasmic sperm injection,ICSI)技术是目前主要的人类辅助生殖技术(assisted reproductive technology,ART)之一。该项技术通过显微操作系统将单个精子注射入卵子,有效地解决了少弱畸形精子症等男性因素相关的不育问题,在全世界产出数百万儿童。目前,越来越多非男性因素不孕症也采用ICSI技术。然而,不同于常规体外受精(in vitro fertilization,IVF)更自然的精卵结合,ICSI技术具有有创性,其安全性受到了人们的关注。本文旨在对ICSI的临床结局及其对子代的影响进行系统综述,从而为ICSI技术的有效性及其对子代安全性问题提供线索和依据。Intracytoplasmic sperm injection(ICSI)is one of the main techniques in assisted reproductive technology(ART)currently.By injecting a single sperm into the egg through microscopy system,ICSI can solve the problem of infertility due to male factors effectively,such as oligoasthenoterazoospermia,producing millions of children around the world.Nowadays,more and more couples with non-male factor infertility use ICSI as well.However,unlike conventional in vitro fertilization(IVF),ICSI technology is invasive and its safety has attracted attention.We systematically reviewed the clinical outcomes of ICSI and its effects on offspring,so as to provide clues and bases for the effectiveness and offspring safety of ICSI.

关 键 词：生殖技术 辅助 精子注射 细胞质内 受精 治疗结果 

分 类 号：R714.8[医药卫生—妇产科学]