1990—2019年中国不孕不育患者的疾病负担研究  

Study on the disease burden of male and female infertility in China from 1990 to 2019

作　　者：刘淳[1] 孙惠昕[2] 马玉琨[1] 徐琳 张艺馨 卢美松[1] Liu Chun;Sun Huixin;Ma Yukun;Xu Lin;Zhang Yixin;Lu Meisong(The Assisted Reproduction Department,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;Institute of Cancer Prevention and Treatment,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属第一医院生殖医学科,哈尔滨150001 [2]哈尔滨医科大学肿瘤防治研究所,哈尔滨150081

出　　处：《中华生殖与避孕杂志》2023年第6期627-631,共5页Chinese Journal of Reproduction and Contraception

摘　　要：目的:分析1990—2019年中国不育不孕的男性和女性的患病情况和疾病负担情况。方法:利用2019年全球疾病负担数据库,分析1990—2019年我国总人群、不同年龄组间不孕不育男性和女性的患病情况和伤残调整寿命年(disability adjusted life year,DALY)。结果:2019年中国男性不育患病数、患病率、DALY和DALY率分别为1457.74万、2011.18/10万、7.79万人年、10.76/10万,女性不孕患病数、患病率、DALY和DALY率分别为3788.43万、5431.22/10万、19.70万人年、28.25/10万,女性的不孕患病和疾病负担情况高于男性。男性患病率和DALY率最高的年龄组分别为35~39岁和30~34岁年龄组,女性患病率和DALY率最高的年龄组分别为40~44岁和35~39岁年龄组,女性患病率和DALY率最高的年龄组较男性晚5岁。1990—2019年,不孕不育男性和女性患病率和DALY率在前20年左右有升高趋势,在后10年左右有降低趋势,但中国不孕不育的男性和女性患病率和DALY率明显高于全球及不同的社会人口学指数(socio-demographic index,SDI)地区。结论:近年来中国不孕不育患病率和DALY率虽然呈降低趋势,但中国人口基数大,在全球范围不孕不育疾病负担占比仍然较大,应采取积极的预防以及治疗措施减轻男女性不孕不育的疾病负担。Objective To analyze the prevalence and disease burden of male and female infertility in China from 1990 to 2019.Methods The global disease burden database of 2019 was used to analyze the prevalence of male and female infertility and disability adjusted life years(DALY)in China from 1990 to 2019 among the total Chinese male and female population and different age groups.ResultsIn 2019,the number,prevalence,DALY and DALY rate of male infertility in China were 14577432,2011.18/100000,77983 person years,1076/100000,respectively.The number,prevalence,DALY and DALY rate of female infertility were 37884300,5431.22/100000,197046 person years,28.25/100000,respectively.The prevalence and disease burden of female infertility were higher than those of male infertility.The age group with the highest male prevalence rate and DALY rate were 35-39 and 30-34 years old respectively,the age group with the highest female prevalence rate and DALY rate were 40-44 and 35-39 years old respectively,and the age group with the highest female prevalence rate and DALY rate was 5 years later than the male age group.From 1990 to 2019,the prevalence rate and DALY rate of male and female infertility increased in the first 20 years or so,and decreased in the last 10 years or so.The prevalence rate and DALY rate of male and female infertility in China were significantly higher than those in the whole world and different socio-demographic index(SDI)regions.ConclusionAlthough the prevalence rate and DALY rate of male and female infertility in China have decreased in recent years,the population base of China is large,and the disease burden of male and female infertility in the world is still large.Active prevention and treatment measures should be taken to reduce the disease burden of male and female infertility.

关 键 词：不育 男性 不孕 女性 疾病负担 患病率 伤残调整寿命年 

分 类 号：R711.6[医药卫生—妇产科学]