西多福韦体外抑制55型人腺病毒的感染  

Cidofovir inhibits human adenovirus type 55 infection in vitro

作　　者：王文博 王梦珂 胡宗海 熊杰 刘媛 Wenbo Wang;Mengke Wang;Zonghai Hu;Jie Xiong;Yuan Liu(Department of Disease Control and Prevention,General Hospital of Western Theater Command,Chengdu 610083,Sichuan,China;Department of Clinical Laboratory,General Hospital of Western Theater Command,Chengdu 610083,Sichuan,China;College of Medical Technology,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan,China)

机构地区：[1]西部战区总医院疾病预防控制科,四川成都610083 [2]西部战区总医院检验科,四川成都610083 [3]成都中医药大学医学技术学院,四川成都610075

出　　处：《Journal of Chinese Pharmaceutical Sciences》2023年第6期473-477,共5页中国药学（英文版）

基　　金：A Project from the Hospital (Grant No. 2021-XZYG-B11);the Key Research and Development Project of the Sichuan Science and Technology Department (Grant No. 2019YFS0367)

摘　　要：55型人腺病毒(HAdV-55)通常引起急性呼吸道感染疾病,目前临床上还没有有效的抗病毒药物。本研究通过体外实验筛选了14种核苷酸类似物的抗HAdV-55活性。结果发现,西多福韦在HEp-2细胞上能够抑制HAdV-55的感染,为其用于HAdV-55感染疾病的治疗研究提供了依据。Human adenovirus type 55(HAdV-55)can usually cause acute respiratory diseases.Unfortunately,there is no available specific antiviral drug.In the present study,14 nucleotide analogs were screened for their anti-HAdV-55 activities in vitro.The results suggested that cidofovir could inhibit HAdV-55 infection in HEp-2 cells,providing strong evidence for further research on treating HAdV-55 infection.

关 键 词：西多福韦 阿德福韦 替诺福韦 腺病毒 HAdV-55 

分 类 号：R978.7[医药卫生—药品]