沙库巴曲缬沙坦对血小板活化、动脉血栓形成的作用  

Effect of Sacubitril Valsartan on Platelet Activation and Thrombus Formation

作　　者：代世摩 戚志勇 齐保振 林佳雄 葛均波 DAI Shimo;QI Zhiyong;QI Baozhen;LIN Jiaxiong;GE Junbo(Department of Cardiology,Zhongshan Hospital,Fudan University,Shanghai Institute of Cardiovascular Diseases,National Clinical Research Center for Interventional Medicine,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院心内科上海市心血管病研究所国家放射与治疗临床医学研究中心,上海市200032

出　　处：《中国分子心脏病学杂志》2023年第3期5380-5386,共7页Molecular Cardiology of China

摘　　要：目的 探索沙库巴曲缬沙坦对血小板活化、动脉血栓形成的作用。方法 通过血小板聚集、释放、P-选择素释放、整合素αⅡbβ3活化、铺展、栓块回缩分析等实验,检测体外孵育沙库巴曲缬沙坦对人血小板活化的作用,通过FeCl3损伤小鼠肠系膜动脉血栓实验分析沙库巴曲缬沙坦对体内动脉血栓形成的作用。结果 沙库巴曲缬沙坦浓度依赖地抑制了凝血酶、胶原、二磷酸腺苷诱导的人血小板聚集、释放,沙库巴曲缬沙坦抑制了P-选择素释放、整合素αⅡbβ3活化、铺展、栓块回缩,沙库巴曲缬沙坦抑制了小鼠体内动脉血栓的形成。结论 沙库巴曲缬沙坦具有抑制血小板活化、抗动脉血栓形成的作用。Objective To explore the effect of sacubitril valsartan on platelet activation and thrombus formation.Methods Platelet aggregation,ATP release,P-selectin release,integrin α Ⅱ bβ3 activation,spreading,and clot retraction were measured to test the effect of sacubitril valsartan on human platelet activation in vitro.FeCl3-induced mesenteric arterial thrombosis model was used to study the effect of sacubitril valsartan on arterial thrombus formation in vivo.Results Sacubitril valsartan inhibited thrombin,collagen,and ADP-induced human platelet aggregation and ATP release in a concentration-dependent manner.Sacubitril valsartan also inhibited P-selectin release,integrin α Ⅱ bβ3 activation,spreading,and clot retraction.In vivo,Sacubitril valsartan inhibited arterial thrombus formation process in mice.Conclusions Sacubitril valsartan has an inhibitory effect on platelet activation and thrombus formation.

关 键 词：沙库巴曲缬沙坦 血小板活化 动脉血栓形成 

分 类 号：R969[医药卫生—药理学]