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作 者:沈怡 章诗涵 杨方星[1] SHEN Yi;ZHANG Shihan;YANG Fangxing(Institute of Environmental Health,College of Environmental&Resourse Sciences,Zhejiang University,Hangzhou,310058,China)
机构地区:[1]浙江大学环境与资源学院环境健康研究所,杭州310058
出 处:《环境化学》2023年第7期2171-2179,共9页Environmental Chemistry
基 金:国家自然科学基金(41977341)资助.
摘 要:随着使用量的增加,可待因在水环境中被频繁检出.然而,可待因对水生生物,尤其是鱼类的不利影响尚不清楚.本文研究了环境浓度暴露下可待因对鲫鱼幼鱼体内神经化学物质的影响.结果表明,可待因(5 ng·L^(−1)和500 ng·L^(−1))暴露7 d后,导致可待因在鲫鱼体内的蓄积,并在7 d的恢复期内表现出持久性.神经化学物质分析显示,鲫鱼体内去甲肾上腺素(NE)、左旋多巴(L-DOPA)、多巴胺(DA)、5-羟色胺(5-HT)、5-羟色氨酸(5-HTP)、蛋氨酸(Met)、天冬氨酸(Asp)和脯氨酸(Prol)水平在暴露后升高,而去甲变肾上腺素(MNE)、谷氨酰胺(Gln)、谷氨酸(Glu)、5-羟基吲哚乙酸(5-HIAA)和甜菜碱(Bet)水平则降低,并且可待因对大多数神经化学物质的影响在7 d的恢复期内具有不可逆性或持续性.环境浓度的可待因暴露能够导致其在鲫鱼体内的蓄积和神经化学物质的变化,由此而产生的神经毒性及其后果值得进一步关注.With the increasing application of codeine(COD),the psychoactive substance has been frequently detected in aquatic environment.However,the adverse effects of COD on aquatic organisms remain unclear,especially on fish.In this study,the effects of COD on neurochemicals were investigated in larve crucian carp at environmentally relevant concentrations.The results revealed that exposure to COD(5 and 500 ng·L^(−1))for 7 days resulted in a persistent accumulation in fish.Analysis on neurochemicals showed that the levels of norepinephrine(NE),3,4-Ldihydroxyphenylalanine(L-DOPA),dopamine(DA),5-hydroxy-L-tryptophan(5-HTP),serotonin(5-HT),L-methionine(Met),L-aspartic acid(Asp)and L-proline(Prol)increased while the levels of norepinephrine(MNE),L-glutamine(Gln),L-glutamic acid(Glu),5-hydroxyindoleacetic acid(5-HIAA)and betaine(Bet)decreased in the fish.Most of such changes of neurochemicals were irreversible or persistent in a 7-day recovery period.The bioaccumulation of COD and alterations of neurochemcials in crucian carp exposed to COD at environmentally relevant concentrations suggest that the neurotoxicity of COD and related adverse outcomes should receive more attentions.
关 键 词:可待因 神经化学物质 神经毒性 生物蓄积 环境相关浓度 鲫鱼.
分 类 号:X503.225[环境科学与工程—环境工程]
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