不同严重程度脓毒血症患儿血清NT-proBNP、SAA和HBP异常表达对预后不良的预测  

Abnormal expression of serum NT-proBNP,SAA and HBP in children with different severity of sepsis predicts poor prognosis

作　　者：朱澹然 乔婕 巩一丁 ZHU Danran;QIAO Jie;GONG Yiding(Department of Pediatrics,Hanzhong 3201 Hospital,Hanzhong,Shaanxi 723000,China)

机构地区：[1]汉中市三二〇一医院儿科,陕西汉中723000

出　　处：《国际检验医学杂志》2023年第15期1811-1814,共4页International Journal of Laboratory Medicine

摘　　要：目的研究不同严重程度脓毒血症患儿血清氨基末端B型钠尿肽原(NT-proBNP)、血清淀粉样蛋白A(SAA)和肝素结合蛋白(HBP)异常表达对预后不良的预测价值。方法选取2018年2月至2021年1月在该院进行治疗的120例脓毒血症患儿作为研究对象,另选取同期来该院体检的健康儿童120例作为对照组,比较观察组与对照组、不同预后、不同严重程度脓毒血症患儿的血清NT-proBNP、SAA和HBP水平之间的差异,研究血清NT-proBNP、SAA和HBP联合检测对患儿死亡的预测价值。结果观察组血清NT-proBNP、SAA和HBP水平显著高于对照组,差异有统计学意义(P<0.05)。极危重组、危重组、非危重组血清NT-proBNP、SAA和HBP水平比较,差异有统计学意义(P<0.05)。死亡组血清NT-proBNP、SAA和HBP水平显著高于生存组,差异有统计学意义(P<0.05)。受试者工作特征曲线显示,血清NT-proBNP、SAA和HBP联合检测的曲线下面积显著高于单项检测。结论不同严重程度脓毒血症患儿血清NT-proBNP、SAA和HBP异常表达对预后不良具有显著的预测价值。Objective To study the predictive value of abnormal expression of serum amino-terminal pro-brain natriuretic peptide(NT-proBNP),serum amyloid A(SAA)and heparin-binding protein(HBP)in children with sepsis of different severity.Methods A total of 120 children with sepsis treated in a hospital from February 2018 to January 2021 were selected as the study object,and 120 healthy children who received physical examination in a hospital during the same period were selected as the control group.The differences of serum NT-proBNP,SAA and HBP levels between the observation group and the control group,children with different prognosis and different severity of sepsis were compared.To investigate the predictive value of combined detection of serum NT-proBNP,SAA and HBP for the death of children.Results The levels of serum NT-proBNP,SAA and HBP in the observation group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).The levels of serum NT-proBNP,SAA and HBP in the extremely critical group,the critical group and the non-critical group were statistically significant(P<0.05).The levels of serum NT-proBNP,SAA and HBP in death group were significantly higher than those in survival group,and the difference was statistically significant(P<0.05).The receiver operating characteristic curve showed that the area under the curve of the combined detection of serum NT-proBNP,SAA and HBP was significantly higher than that of the single detection.Conclusion Abnormal expression of serum NT-proBNP,SAA and HBP in serum of children with different severity of sepsis has significant predictive value for poor prognosis.

关 键 词：脓毒血症 预后 血清氨基末端B型钠尿肽原 血清淀粉样蛋白A 肝素结合蛋白 

分 类 号：R459.7[医药卫生—急诊医学]