某院狼疮抗凝物检测阳性人群分布特征分析  

Analysis of the distribution characteristics of positive lupus anticoagulant test population in a hospital

作　　者：姜华[1] 黎浩然 王丹[1] 孙越红[1] 韩平 张晨曦 龚晨[1] 李虓[1] 李芬芬[1] 张丽敏[1] JIANG Hua;LI Haoran;WANG Dan;SUN Yuehong;HAN Ping;ZHANG Chenxi;GONG Chen;LI Xiao;LI Fenfen;ZHANG Limin(Laboratory Diagnosis Center,Beijing Tiantan Hospital,Capital Medical University/Beijing Engineering Research Center of Immunological Reagents Clinical Research/NMPA Key Laboratory for Quality Control of In Vitro Diagnostics,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院实验诊断中心/北京市免疫试剂临床工程技术研究中心/国家药监局体外诊断试剂质量控制重点实验室,北京100070

出　　处：《国际检验医学杂志》2023年第15期1848-1852,共5页International Journal of Laboratory Medicine

基　　金：北京天坛医院院青年科学基金(2016-YQN-09);首都医科大学科研培育基金(PYZ2017067)。

摘　　要：目的分析首都医科大学附属北京天坛医院狼疮抗凝物(LA)检测阳性人群分布特征。方法回顾性收集2016年1月至2022年10月于该院就诊并行实验室LA检测人群的信息,根据患者年龄、性别、疾病谱及阳性检出情况进行分类汇总,共纳入3403例患者(观察组)。另选取同期来该院进行体检的健康人群作为对照组。LA检测分别采用二氧化硅凝固时间(SCT)法和改良的稀释蝰蛇毒时间(dRVVT)法并根据其阳性检出情况分为dRVVT阳性,SCT阳性及双阳。结果两组LA检测人群平均年龄比较差异有统计学意义(P<0.05)。观察组检出LA阳性患者384例,检出率为11.28%,对照组检出LA阳性患者146例,检出率为13.33%,差异无统计学意义(P>0.05)。观察组LA阳性患者的男性占比为45.57%,低于对照组LA阳性患者的男性占比(87.67%),差异有统计学意义(P<0.05)。结论分析LA检测阳性人群分布特征对患者病因学探索及进一步预防血栓事件的发生具有重要的意义。Objective To analyze the distribution characteristics of lupus anticoagulant(LA)positive population in Beijing Tiantan Hospital,Capital Medical University.Methods The information of patients admitted to a Hospital from January 2016 to October 2022 for laboratory LA testing was retrospectively collected,and classified and summarized according to age,gender,disease spectrum and positive detection of patients.A total of 3403 patients(observation group)were included.The subjects who came to a hospital for physical examination during the same period were included as the control group.LA was tested by silica clotting time(SCT)or diluted improved russell viper venom time(dRVVT)method respectively.LA positive results were divided into three subgroups as follow:dRVVT positive group,SCT positive group and double positive group.Results There was significant difference in average age between the two groups(P<0.05).There were 384 LA positive patients in the observation group,the detection rate was 11.28%,and 146 LA positive patients in the control group,the detection rate was 13.33%,with no statistical significance(P>0.05).The male proportion of LA positive patients in the observation group was 45.57%,lower than that in the control group(87.67%),and the difference was statistically significant(P<0.05).Conclusion It is of great significance to analyze the distribution characteristics of LA positive population for etiology exploration and further prevention of thrombotic events.

关 键 词：狼疮抗凝物 脑梗死 血栓 凝血 

分 类 号：R446.6[医药卫生—诊断学]