糖尿病合并颈动脉斑块患者血浆ox-LDL-C与氧化应激相关性研究  

Correlation between plasma ox-LDL-C and oxidative stress in patients with diabetes mellitus complicated with carotid plaque

作　　者：张晶梅 苏珍珍 徐秀芬 王占武 李青影 武入英 王占科 ZHANG Jingmei;SU Zhenzhen;XU Xiufen;WANG Zhanwu;LI Qingying;WU Ruying;WANG Zhanke(Department of Blood Transfusion,Xingtai Third Hospital,Xingtai,Hebei 054000,China;College of Laboratory Medicine,Hebei North University,Zhangjiakou,Hebei 075000,China;Department of Endocrinology,Ningbo Yinzhou Hospital of Traditional Chinese Medicine,Ningbo,Zhejiang 315100,China;Department of Endocrinology,Xingtai Third Hospital,Xingtai,Hebei 054000,China;Department of Clinical Laboratory,Hebei Provincial Veterans General Hospital,Xingtai,Hebei 054000,China;Department of VAP Lipid Subcomponents Laboratory,Ningbo Meikang Shengde Medical Laboratory,Ningbo,Zhejiang 315100,China;Academician Workstation of Ningbo Health Vocational and Technical College,Ningbo,Zhejiang 315100,China)

机构地区：[1]邢台市第三医院输血科,河北邢台054000 [2]河北北方学院检验学院,河北张家口075000 [3]宁波鄞州中医院内分泌科,浙江宁波315100 [4]邢台市第三医院内分泌科,河北邢台054000 [5]河北省退役军人总医院检验科,河北邢台054000 [6]宁波美康盛德医学检验所VAP血脂亚组分实验室,浙江宁波315100 [7]宁波卫生职业技术学院院士工作站,浙江宁波315100

出　　处：《国际检验医学杂志》2023年第15期1863-1867,共5页International Journal of Laboratory Medicine

基　　金：邢台市科技局重点课题(2020ZC358)。

摘　　要：目的研究糖尿病合并颈动脉斑块患者血清氧化性低密度脂蛋白胆固醇(ox-LDL-C)与氧化应激相关性,并探讨糖尿病患者易发生动脉粥样硬化的可能机制。方法选取2019年6月1日至2022年7月1日邢台市第三医院内分泌科收治的糖尿病患者156例(单纯糖尿病组)和糖尿病合并颈动脉斑块患者170例(糖尿病合并颈动脉斑块组)作为研究对象,另选取同期来该院体检的健康者179例作为健康对照组。测定各组血清ox-LDL-C、低密度脂蛋白胆固醇(LDL-C)、小而密低密度脂蛋白胆固醇(sdLDL-C)、超氧化酶歧化酶(SOD)和丙二醛(MDA)等指标,计算ox-LDL-C/LDL-C和ox-LDL-C/sdLDL-C,分析3组间各检测指标变化,以及单纯糖尿病组和糖尿病合并颈动脉斑块组患者血清ox-LDL-C、ox-LDL-C/LDL-C和ox-LDL-C/sdLDL-C与SOD活力和MDA之间相关性。结果糖尿病合并颈动脉斑块组和单纯糖尿病组抽烟率和酗酒率及高血压率明显高于健康对照组,糖尿病合并颈动脉斑块组高血压率明显高于单纯糖尿病组,差异有统计学意义(P<0.05)。糖尿病合并颈动脉斑块组和单纯糖尿病组血清ox-LDL-C、LDL-C、ox-LDL-C/LDL-C、sdLDL-C、ox-LDL-C/sdLDL-C和MDA水平均明显高于健康对照组,差异有统计学意义(P<0.05)。单纯糖尿病组和糖尿病合并颈动脉斑块组患者血清ox-LDL-C、ox-LDL-C/LDL-C、ox-LDL-C/sdLDL-C与SOD活力呈负相关(r=-0.534、-0.446、-0.720,P<0.05);与MDA呈正相关(r=0.606、0.494、0.819,P<0.05)。结论糖尿病合并颈动脉斑块患者血清ox-LDL-C、ox-LDL-C/sdLDL-C和ox-LDL-C/LDL-C明显升高,可能与糖尿病患者存在氧化应激有关。Objective To study the correlation between serum oxidized low-density lipoprotein cholesterol(ox-LDL-C)and oxidative stress in patients with diabetes mellitus combined with carotid plaque and to investigate the mechanism of atherosclerosis in diabetic patients.Methods A total of 156 patients with diabetes(simple diabetes group)and 170 patients with diabetes mellitus combined with carotid plaque(diabetes mellitus combined with carotid plaque group)admitted to the Department of Endocrinology of Xingtai Third Hospital from June 1,2019 to July 1,2022 were selected as the study objects,and 179 healthy patients who came to the hospital for physical examination during the same period were selected as the healthy control group.Serum ox-LDL-C,low-density lipoprotein cholesterol(LDL-C),small and dense low-density lipoprotein cholesterol(sdLDL-C),superoxidase dismutase(SOD)and malondialdehyde(MDA)were measured in each group,and ox-LDL-C/LDL-C and ox-LDL-C/sdLDL-C were calculated.The changes of various detection indexes among the three groups were analyzed,and the correlation between serum ox-LDL-C,ox-LDL-C/LDL-C and ox-LDL-C/sdLDL-C and SOD activity and MDA in patients with simple diabetes and diabetes mellitus with carotid plaque was analyzed.Results The smoking rate,alcoholism rate and hypertension rate of diabetes mellitus combined with carotid plaque group and simple diabetes group were significantly higher than those of healthy control group,and the hypertension rate of diabetes mellitus combined with carotid plaque group was significantly higher than that of simple diabetes group,the difference was statistically significant(P<0.05).Serum levels of ox-LDL-C,LDL-C,ox-LDL-C/LDL-C,sdLDL-C,ox-LDL-C/sdLDL-C and MDA in diabetes mellitus combined with carotid plaque group and simple diabetes group were significantly higher than those in healthy control group,with statistical significance(P<0.05).Serum ox-LDL-C,ox-LDL-C/LDL-C,ox-LDL-C/sdLDL-C were negatively correlated with SOD activity(r=-0.534,-0.446,-0.720,P<0.05).It was po

关 键 词：糖尿病 颈动脉斑块 低密度脂蛋白胆固醇 氧化应激 动脉粥样硬化性心脑血管疾病 

分 类 号：R587.2[医药卫生—内分泌]