肠干细胞调控与肠道放射损伤修复的研究进展  

Regulation of intestinal stem cells and tissue damage and repair after radiation exposure

作　　者：贺林凤 曹雨 张宁[1] 冉新泽[1] 王锋超[1] He Linfeng;Cao Yu;Zhang Ning;Ran Xinze;Wang Fengchao(Institute of Combined Injury of PLA,State Key Laboratory of Trauma,Burn and Combined Injury,College of Preventive Medicine;College of Basic Medical Sciences,Army Medical University(Third Military Medical University),Chongqing 400038,China)

机构地区：[1]陆军军医大学(第三军医大学)军事预防医学系全军复合伤研究所创伤、烧伤与复合伤国家重点实验室,重庆400038 [2]陆军军医大学(第三军医大学)军事预防医学系全军复合伤研究所基础医学院,重庆400038

出　　处：《中华损伤与修复杂志（电子版）》2023年第4期358-363,共6页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：国家自然科学基金面上项目(81872556);重庆市院士专项(基础研究与前沿探索类)(cstc2018jcyj-yszxX0004);陆军军医大学创新能力提升项目(2021XJS03)。

摘　　要：肠道是放射损伤的重要靶器官,其损伤修复程度直接影响放射复合伤及其他肠道放射损伤患者的病情转归,目前临床尚缺乏有效的防治手段。肠道干细胞调控在放射性肠损伤的发展进程中居于核心地位。对肠道干细胞鉴定、信号调控、再生修复病理过程和相关药物靶点筛选等方面的研究,可为治疗相关疾病提供参考。Intestinal tract is an important target organ of radiation injury.The degree of tissue damage and repair directly affects the prognosis of patients with radiation combined injury and other type of intestinal radiation injuries.So far,there is still a lack of effective clinical methods to treat radiation damage.The regulation of intestinal stem cells plays a central role in the development of radiation-induced intestinal injury.Study on intestinal stem cells identity,signal regulation,pathological process and drug screening,can provide references for the treatment of related diseases.

关 键 词：肠干细胞 信号调控 放射 组织损伤修复 

分 类 号：R605[医药卫生—外科学]