加味六君子汤治疗脾虚痰聚型抽动障碍的临床疗效观察  

Clinical Observation on Jiawei Liujunzi Decoction in Treatment of Tic Disorder with Spleen Deficiency and Phlegm Accumulation Type

作　　者：董秀玲 李兆坤[2] 李亚群 DONG Xiu-ling;LI Zhao-kun;LI Ya-qun(Center of Integrative Chinese and Western Medicine,Medical Science Center of Qingdao University,Qingdao Shandong,266000,China;Department of Neonatology,Weifang Hospital of Traditional Chinese Medicine,Weifang Shandong,261000,China;Department of Pediatrics,Weifang Hospital of Traditional Chinese Medicine,Weifang Shandong,261000,China)

机构地区：[1]青岛大学医学部中西医结合中心,山东青岛266000 [2]潍坊市中医院新生儿科,山东潍坊261000 [3]潍坊市中医院儿科,山东潍坊261000

出　　处：《中华养生保健》2023年第16期25-30,共6页CHINESE HEALTH CARE

基　　金：潍坊市科学技术发展计划(软科学部分)(2020RKX065)。

摘　　要：目的探讨加味六君子汤对脾虚痰聚型抽动障碍的临床疗效。方法选取2021年10月—2022年5月潍坊市中医院收治的76例符合脾虚痰聚型抽动障碍患儿作为研究对象,按照随机数表法随机分为两组。对照组38例,予口服盐酸硫必利片治疗;观察组38例,在对照组基础上予加味六君子汤治疗。两组均治疗8周。统计并比较两组患儿抽动症状改善情况、中医证侯积分,检测并比较治疗前后患儿晨间空腹上肢静脉血中神经递质水平、T淋巴细胞亚群水平、维生素A、维生素D水平。结果治疗后,两组患儿抽动情况以及中医证侯积分较治疗前均有改善,观察组患儿耶鲁综合抽动严重程度量表(YGTSS)评分、中医症状评分均低于对照组,差异均具有统计学意义(P<0.05)。治疗后,两组患儿血清白细胞介素-6(IL-6)、5-羟色胺(5-HT)、多巴胺(DA)水平均低于治疗前,γ-氨基丁酸(GABA)水平高于治疗前,且观察组IL-6、5-HT、DA水平低于对照组,GABA水平高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患儿CD3+、CD4+、CD4+/CD8+水平均高于治疗前,CD8+水平低于治疗前,且观察组CD3+、CD4+、CD4+/CD8+水平高于对照组,CD8+水平低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患儿维生素A、维生素D水平有所提高,且观察组维生素A、维生素D水平高于对照组,差异具有统计学意义(P<0.05)。结论加味六君子汤联合盐酸硫必利对脾虚痰聚型抽动障碍患儿抽动症状有更有效的治疗作用,对患儿神经递质水平以及免疫功能也有更好的改善作用,值得在临床应用。Objective To investigate the eff ect of Jiawei Liujunzi Decoction in treating tic disorder of spleen defi ciency and phlegm accumulation type.Methods A total of 76 children with tic disorder of spleen defi ciency and phlegm accumulation type admitted to the pediatric clinic of Weifang Hospital of traditional Chinese medicine 10.2021~5.2022 were seperated into two groups by random numbers.38 cases in the control group were treated with tiapride hydrochloride tablets;38 cases in the observation group were treated with Jiawei Liujunzi Decoction.Duration of two groups’treatment were 8 weeks.The score of YGTSS,TCM symptoms,the levels of neurotransmitters,T lymphocyte subsets,vitamin A and vitamin D were detected and compared.Results The YGTSS and TCM symptom score of the children treated with Jiawei Liujunzi Decoction were lower than those treated with tiapride after treatment(P<0.05).The levels of IL-6,5-HT and dopamine in the two groups after treatment were lower than those before treatment,GABA was higher than that before treatment,the range of changes in these indicators in the observation group were more remarkable than those in the control group after treatment(P<0.05).After treatment,the levels of CD3+、CD4+、CD4+/CD8+in the two groups were raised than 8 weeks before,and the levels of CD8+were lower than 8 weeks before.The range of changes in these indicators in the observation group were more remarkable than those in the control group after treatment(P<0.05).The levels of Vit A and Vit D in the observation group were higher than those in the control group(P<0.05).Conclusion Jiawei Liujunzi Decoction has a more eff ective therapeutic eff ect on the tic symptoms of spleen defi ciency and phlegm accumulation,and has a better eff ect on the level of neurotransmitters and immune function of children,which is worthy of clinical application.

关 键 词：抽动障碍 加味六君子汤 盐酸硫必利片 脾虚痰聚型 

分 类 号：R277.7[医药卫生—中医学]