人类免疫缺陷病毒感染者衰弱状况评估方法研究  

Assessment of frailty in people living with HIV using three different frailty assessment tools

作　　者：杨梦茹 吴文林 许晓蕾 何坤[2] 李奇穗[2] 李明俊 刘敏[2] 陈耀凯 YANG Mengru;WU Wenlin;XU Xiaolei;HE Kun;LI Qisui;LI Mingjun;LIU Min;CHEN Yaokai(School of Public Health,Zunyi Medical University,Zunyi Guizhou 563000,China)

机构地区：[1]遵义医科大学公共卫生学院,贵州遵义563000 [2]重庆市公共卫生医疗救治中心感染科

出　　处：《中国感染与化疗杂志》2023年第4期455-458,共4页Chinese Journal of Infection and Chemotherapy

基　　金：重庆市科卫联合医学科研项目(2020FYYX118,2022QNXM032);重庆市科技局人才项目(cstc2021ycjh-bgzxm0275);重庆市技术创新与应用发展专项(cstc2020jscx-cylhX0001)。

摘　　要：目的了解我国人类免疫缺陷病毒(HIV)感染者衰弱状况,并研究不同衰弱评估方法对于中国HIV感染者的适用性、一致性和可操作性。方法选取≥35岁的HIV感染者200例,采用Fried衰弱表型(frailty phenotype,FP)、衰弱指数(frailty index,FI)、衰弱量表(frail scale,FS)进行衰弱状况评估,比较三种评估方法的检出率、一致性和可操作性。结果研究对象平均年龄55.8岁,CD4+T淋巴细胞计数中位数为234.5(112.3,406.5)/μL。衰弱前期和衰弱检出率分别为39.5%和11.0%(FP)、24.5%和19.0%(FI),49.0%和8.5%(FS);两两比较,FP与FI、FP与FS、FI与FS之间一致性评估结果的Kappa值分别为0.361、0.335、0.378(P<0.001),具有较弱的一致性。三种衰弱评估方法的可操作性具有差异。结论我国HIV感染者衰弱或衰弱前期发生率较高,三种衰弱评估方法检出效率具有一致性,但可操作性存在差异,可根据不同应用场景选择使用。Objective To assess the prevalence of frailty in Chinese people living with HIV,and compare the utility of three frailty assessment tools in terms of applicability,result consistency,and operability.Methods A total of 200 people living with HIV and≥35 years of age were enrolled in this study.Frailty Phenotype(FP),Frailty Index(FI)and FRAIL Scale(FS)were used to assess their frailty.The three assessment tools were compared in terms of frailty detection rate,consistency in frailty detection,and operability.Results The mean age of the 200 participants was 55.8 years.The median CD4+T lymphocyte count was 234.5(112.3,406.5)cells/μL.The prevalence of prefrailty and frailty was 39.5%and 11.0%assessed by FP,24.5%and 19.0%by FI,49.0%and 8.5%by FS.The Kappa value of detection rate consistency between FP and FI,between FP and FS,and between FI and FS was 0.361,0.335 and 0.378(P<0.001),respectively,indicating frailty consistency between the results of the three tools.The three frailty assessment tools demonstrated different operability.Conclusions The prevalence of frailty and prefrailty is high in the Chinese people living with HIV.FP,FI and FS are comparable in the performance of frailty assessment.However,the three tools are different in operability.Their utility varies in different scenarios.

关 键 词：人类免疫缺陷病毒 衰弱 评估 

分 类 号：R512.91[医药卫生—内科学]