阿莫西林克拉维酸钾辅助治疗过敏性紫癜的疗效观察及对相关炎症因子表达的影响  

Efficacy of Amoxicillin clavulanate potassium in the adjuvant treatment of Henoch⁃Schonlein Purpura and its effect on the expression of related inflammatory factors

作　　者：安永涛 高睿迪 方险峰[3] AN Yongtao;GAO Ruidi;FANG Xianfeng(Department of Dermatology,Funan County People's Hospital,Funan,Anhui,China,236300;Depart-ment of Dermatology,Fuyang People's Hospital,Fuyang,Anhui,China,236000;Department of Derma-tology,the First Clinical Medical College of Three Gorges University,Yichang,Hubei,China,443003)

机构地区：[1]安徽省阜南县人民医院皮肤科,安徽阜南236300 [2]安徽省阜阳市人民医院皮肤科,安徽阜阳236000 [3]三峡大学第一临床医学院皮肤科,湖北宜昌443003

出　　处：《分子诊断与治疗杂志》2023年第7期1108-1111,共4页Journal of Molecular Diagnostics and Therapy

基　　金：国家自然科学基金(81260593);阜阳市科研立项课题(FY2019⁃037)。

摘　　要：目的探讨阿莫西林克拉维酸钾辅助治疗过敏性紫癜的临床疗效,以及对相关炎症因子表达的影响。方法100例过敏性紫癜患儿随机分为观察组和对照组,每组50例。对照组采用糖皮质激素、抗组胺药治疗,观察组在对照组治疗基础上加用阿莫西林克拉维酸钾,治疗结束后观察患者住院时间、治愈率及复发例数,检测各组患者ASO、CRP以及IL⁃2、INF⁃γ、IL⁃4、IL⁃10的表达水平,并进行对比分析。结果观察组患者在住院时间、治愈率以及复发例数方面,显著优于对照组,差异具有统计学意义(t=3.80;χ^(2)=6.25,9.76,P均<0.05)。治疗前两组患者相关炎症因子表达水平差异无统计学意义。(P>0.05)。治疗后,对照组患者相关炎症因子无明显变化,而观察组则出现ASO、CRP、IL⁃4、IL⁃10明显下降,IL⁃2、INF⁃γ显著上升,治疗前后对照,差异具有统计学意义(t=13.88,26.27,8.21,6.95,14.41,6.96,P均<0.05),治疗后两组间比较差异也具有统计学意义(t=37.17,17.60,7.29,4.80,18.10,7.51,P均<0.05)。结论阿莫西林克拉维酸钾能有效控制紫癜患者潜在感染,间接影响机体免疫,减少患者复发,作为辅助用药治疗儿童过敏性紫癜疗效确切。Objective To investigate the clinical efficacy of Amoxicillin clavulanate potassium in the adjuvant treatment of Henoch⁃Schonlein Purpura(HSP)and its effect on the expression of related inflam⁃matory factors.Methods 100 children with HSP were randomly divided into the observation group and the control group,with 50 cases in each group.The control group was treated with GC and antihistamines,while the observation group was given Amoxicillin clavulanate potassium therapy based on the control group.After treatment,the hospitalization time,cure rate and the number of recurrent cases were compared between the two groups.The expression levels of ASO,CRP and IL⁃2,INF⁃γ,IL⁃4,IL⁃10 in each group were detected and compared.Results The observation group was significantly better than the control group in the hospital⁃ization time,cure rate and the number of recurrence cases(t=2.10;χ^(2)=6.25,9.76,P<0.05).Before treat⁃ment,there was no significant change in related inflammatory factors between the two groups(P>0.05).After treatment,there was no significant change in related inflammatory factors in the control group,while ASO,CRP,IL⁃4,IL⁃10 decreased significantly and IL⁃2,INF⁃γincreased significantly in the observation group.The difference was statistically significant before and after treatment(t=13.88,26.27,8.21,6.95,14.41,6.96,P<0.05),and the difference between the two groups after treatment was also statistically significant(t=37.17,17.60,7.29,4.80,18.10,7.51,P<0.05).Conclusion Amoxicillin clavulanate potassium can effec⁃tively control the potential infection of patients with HSP,indirectly affect the body immunity and reduce the recurrence of patients.As an adjuvant drug,Amoxicillin clavulanate potassium has a definite curative effect in the treatment of children with HSP.

关 键 词：过敏性紫癜 阿莫西林克拉维酸钾 炎症因子 

分 类 号：R725.5[医药卫生—儿科]