CA125、hs⁃CRP及Hcy检测在急性心衰诊断、近期预后中的评估  

Role of CA125,hs⁃CRP and Hcy in diagnosis and short⁃term prognosis assessment ofacute heart failure

作　　者：刘金成 陈东 李佳 张盛 张应宝 汪彬 LIU Jincheng;CHEN Dong;LI Jia;ZHANG Sheng;ZHANG Yingbao;WANG Bin(Department of Cardiology,Jinzhai County People's Hospita,Lu'an,AnHui,China,237300;Department of Cardiology,the Second People's Hospital of Hefei(Hefei Hospital Affiliated to AnHui Medical University),Hefei,AnHui,China,230011)

机构地区：[1]金寨县人民医院心血管内科,安徽六安237300 [2]合肥市第二人民医院(安徽医科大学附属合肥医院)心血管内科,安徽合肥230011

出　　处：《分子诊断与治疗杂志》2023年第7期1121-1124,共4页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省卫生计生委科研计划项目(2017QK062)。

摘　　要：目的研究糖类抗原125(CA125)、超敏C反应蛋白(hs⁃CRP)、同型半胱氨酸(Hcy)检测在急性心衰诊断、近期预后评估中的作用。方法选取2021年1月至2022年1月金寨县人民医院收治的急性心衰患者98例为试验组,另选取同期本院体检中心各项体检指标正常者95名为对照组。对比不同人群、试验组不同心功能分级CA125、hs⁃CRP及Hcy水平,比较不同预后情况各项指标;采用Cox回归模型评估影响急性心衰患者预后风险的多因素。结果试验组CA125、hs⁃CRP及Hcy水平均高于对照组,差异具有统计学意义(P<0.05)。CA125、hs⁃CRP及Hcy水平:Ⅳ级>Ⅲ级>Ⅱ级,差异具有统计学意义(P<0.05)。据随访结果,预后良好组74例,预后不良组24例;两组年龄、冠心病史、高血压史、糖尿病史、心功能分级、总胆固醇比较差异无统计学意义(P<0.05);两组性别、LVEF、总胆红素、CA125、hs⁃CRP及Hcy水平比较差异具有统计学意义(P<0.05)。将试验组各项指标采用Cox比例风险模型分析,最后进入主效应方程的因素为LVEF、总胆红素、CA125、hs⁃CRP及Hcy水平,LVEF<30%、总胆红素、CA125、hs⁃CRP及Hcy水平异常是影响急性心衰患者预后风险的多因素(P<0.05)。结论CA125、hs⁃CRP及Hcy检测在急性心衰诊断、近期预后评估中具有重要价值,可为指导临床进一步诊断、治疗提高理论基础,对延缓患者病情发展、延长生存时间具有积极作用。Objective To study the effects on the detection of carbohydrate antigen 125(CA125),hypersensitive C⁃reactive protein(hs⁃CRP),Homocysteine(Hcy)in the diagnosis of acute heart failure and short⁃term prognosis assessment.Methods Ninety⁃eight patients with acute heart failure admitted to Jinzhai County People's Hospital from January 2021 to January 2022 were selected as the experimental group,and 95 patients with normal physical examination indexes in the physical examination center of our hospital were selected as the control group.The levels of CA125,hs⁃CRP,and Hcy in different populations and test groups were compared,and the indicators of different prognosis were compared.Cox regression model was used to evaluate the multiple factors affecting the prognosis risk of patients with acute heart failure.Results The levels of CA125,hs⁃CRP and Hcy in the experimental group were higher than those in the control group,and the difference was statistically significant(P<0.05).The levels of CA125,hs⁃CRP and Hcy:Ⅳ>Ⅲ>Ⅱ,and the difference was statistically significant(P<0.05).According to the follow⁃up results,there were 74 cases in the good prognosis group and 24 cases in the poor prognosis group.There was no significant difference in age,history of coronary heart disease,history of hypertension,history of diabetes,cardiac function grade,and total cholesterol between the two groups(P<0.05).There were statistically significant differences in gender,LVEF,total bilirubin,CA125,hs⁃CRP and Hcy levels between the two groups(P<0.05).The indicators of the experimental group were analyzed by Cox proportional hazards model,LVEF<30%,abnormal levels of total bilirubin,CA125,hs⁃CRP and Hcy are multiple factors affecting the prognosis risk of patients with acute heart failure(P<0.05).Conclusion The detection of CA125,hs⁃CRP and Hcy is of great value in the diagnosis of acute heart failure and the assessment of short⁃term prognosis,which can guide clinical further diagnosis and improve the theoretical basis of t

关 键 词：CA125 hs⁃CRP HCY 急性心衰 

分 类 号：R541.6[医药卫生—心血管疾病]