血清Hcy、ADAM10、Gal⁃3与2型糖尿病患者颈动脉粥样硬化的相关性  

Correlation between serum Hcy,ADAM10,Gal⁃3 and carotid atherosclerosis in patients with type 2 diabetes mellitus

作　　者：李丽莉 薛云松 李奕平[2] 赵东岩 李宜铮 LI Lili;XUE Yunsong;LI Yiping;ZHAO Dongyan;LI Yizheng(Department of Clinical Laboratory,the Affiliated Hospital of Yunnan University,Kunming,Yunnan,China,650031;Department of Endocrinology,the Affiliated Hospital of Yunnan University,Kunming,Yunnan,China,650031)

机构地区：[1]云南大学附属医院医学检验科,云南昆明650031 [2]云南大学附属医院医学内分泌科,云南昆明650031

出　　处：《分子诊断与治疗杂志》2023年第7期1199-1202,1211,共5页Journal of Molecular Diagnostics and Therapy

基　　金：云南省科技厅科技计划项目[2019FE001(⁃092)]。

摘　　要：目的探究血清同型半胱氨酸(Hcy)、解整合素⁃金属蛋白酶10(ADAM10)、半乳糖凝集素3(Gal⁃3)与2型糖尿病(T2DM)患者颈动脉粥样硬化(CAS)的相关性。方法选取云南大学附属医院2021年10月至2022年10月收治的98例T2DM患者为观察组,另根据性别、年龄匹配选取同期体检健康者40名为对照组。检验所有研究对象血清Hcy、ADAM10、Gal⁃3水平,对比2组指标差异,分析各项指标与CAS的关系。结果观察组共45例患者纳入T2DM组,53例纳入T2DM+CAS组,三组研究对象的BMI、FBG、2 h FBG、HbA1c、TC、TG、HDL⁃C、LDL⁃C、Hcy、ADAM10、Gal⁃3及左右侧颈动脉内膜中层厚度(intimal media thickness,IMT)水平比较,差异有统计学意义(F=61.934、67.925、65.751、24.465、305.08、24.638、24.789、133.902、43.027、183.94、305.08、265.287,P<0.05)。T2DM+CAS组患者的TC、LDL⁃C、Hcy、ADAM10、Gal⁃3及左右侧IMT水平均高于T2DM组,差异有统计学意义(t=3.064、12.111、8.168、7.575、8.568、12.111、12.089,P<0.05)。观察组患者左侧IMT与ADAM10存在中等程度相关,与Hcy、Gal⁃3存在强相关(r=0.524、0638、0.609,P<0.05);右侧IMT与Hcy、ADAM10、Gal⁃3存在强相关(r=0.699、0.609、0.693,P<0.05)。回归模型中,Hcy、ADAM10、Gal⁃3均为T2DM患者CAS的危险因素(P<0.05)。结论T2DM患者CAS的发生发展受多方面因素,其中血清Hcy、ADAM10、Gal⁃3水平升高均会加重CAS病情,临床上需要加以重视。Objective To explore serum homocysteine(Hcy),adistintegrin and metalloprotein⁃ase 10(ADAM10),Galactose lectin(Gal⁃3)and the correlation with carotid atherosclerosis(CAS)in pa⁃tients with type 2 diabetes(T2DM).Methods 98 patients with T2DM admitted to our hospital from October 2021 to October 2022 were selected as the observation group,and 40 healthy patients were selected as the con⁃trol group according to gender and age matching during the same period.Serum Hcy,ADAM10 and Gal⁃3 lev⁃els among all subjects were tested,and the relationship between each indicator and CAS was analyzed.Results A total of 45 patients in the observation group were included in the T2DM group and 53 patients in the T2DM+CAS group.BMI,FBG,2h FBG,HbA1c,TC,TG,HDL⁃C,LDL⁃C,Hcy,ADAM10,Gal⁃3 and left and right intimal media thickness(IMT)levels of the three groups were compared.The difference was statistically significant(F=61.934,67.925,65.751,24.465,305.08,24.638,24.789,133.902,43.027,183.94,305.08,265.287,P<0.05).The levels of TC,LDL⁃C,Hcy,ADAM10,Gal⁃3 and IMT in the T2DM+CAS group were higher than those in the T2DM group,and the differences were statistically significant(t=3.064,12.111,8.168,7.575,8.568,12.111,12.089,P<0.05).In the observation group,left IMT was moderately corre⁃lated with ADAM10,and strongly correlated with Hcy and Gal⁃3(r=0.524,0638,0.609,P<0.05).On the right,IMT was strongly correlated with Hcy,ADAM10 and Gal⁃3(r=0.699,0.609,0.693,P<0.05).In the re⁃gression model,Hcy,ADAM10 and Gal⁃3 were all risk factors for CAS in T2DM patients(OR=3.461,74.132,15.017,P<0.05).Conclusion The occurrence and development of CAS in T2DM patients are influ⁃enced by multiple factors,among which elevated levels of serum Hcy,ADAM10,and Gal⁃3 can exacerbate the condition of CAS,which needs to be taken seriously in clinical practice.

关 键 词：2型糖尿病 颈动脉粥样硬化 同型半胱氨酸 解整合素⁃金属蛋白酶10 半乳糖凝集素3 

分 类 号：R587.1[医药卫生—内分泌]