血清AngⅡ、apoB/apoA⁃1联合endocan对高血压患者并发冠心病的预测价值  

The predictive value of serum AngⅡ,apoB/apoA⁃1 combined with endocan in hypertensive patients with coronary heart disease

作　　者：董丹萍[1] 谢芳[1] 热衣拉·买买提 许玉荣[1] 郭自同[1] DONG Danping;XIE Fang;REYILA·Maimaiti;XU Yurong;GUO Zitong(Department of Cardiovascular Medicine,Xinjiang Uygur Autonomous Region People's Hospital,Xinjiang,China,830000)

机构地区：[1]新疆维吾尔自治区人民医院心血管内科,新疆830000

出　　处：《分子诊断与治疗杂志》2023年第7期1238-1242,共5页Journal of Molecular Diagnostics and Therapy

基　　金：新疆维吾尔自治区人民医院院内项目(20210241)。

摘　　要：目的探讨血清血管紧张素Ⅱ(AngⅡ)、载脂蛋白B与载脂蛋白A⁃1比值(apoB/apoA⁃1)联合人血管内皮细胞特异性分子(endocan)对高血压患者并发冠心病的预测价值。方法选择2019年4月至2021年12月期间新疆维吾尔自治区人民医院收治的50例高血压合并冠心病的住院患者,设为高血压合并冠心病组;另选取同期本院收治的48例单纯高血压的住院患者,设为单纯高血压组。收集所有患者的基线资料(年龄、性别、吸烟等)和实验室检测指标[收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、血清AngⅡ、apoB/apoA⁃1、endocan等]。采用单因素和多因素Logistic回归分析血清AngⅡ、apoB/apoA⁃1联合endocan与高血压患者并发冠心病的关系,并进一步绘制ROC曲线分析血清AngⅡ、apoB/apoA⁃1、endocan单独及联合检测对高血压患者并发冠心病的预测价值。结果两组高血压病程、LDL⁃C、血清AngⅡ、apoB、apoA⁃1、apoB/apoA⁃1、endocan比较,差异有统计学意义(χ^(2)/t=4.044、4.093、2.908、2.699、2.629、4.528、4.244,P<0.05)。多因素Logistic回归分析结果显示,高血压病程、LDL⁃C、血清AngⅡ、apoB/apoA⁃1、endocan是影响高血压患者并发冠心病的独立危险因素(P<0.05)。ROC曲线结果显示,血清AngⅡ、apoB/apoA⁃1、endocan单独检测预测高血压患者并发冠心病的曲线下面积分别为0.692、0.713、0.701,三者联合检测的曲线下面积最大,为0.831(P<0.05)。结论高血压患者并发冠心病发生风险与其血清AngⅡ、apoB/apoA⁃1、endocan密切相关,三者联合检测的诊断效能更高,且检测方法简便,可为早期预防及诊断高血压患者并发冠心病提供科学参考。Objective To investigate the predictive value of serum angiotensinⅡ(AngⅡ),apoli⁃poprotein B and apolipoprotein A⁃1 ratio(apoB/apoA⁃1)combined with human vascular endothelial cell specif⁃ic molecule(endocan)in patients with hypertension complicated with coronary heart disease.Methods Fif⁃ty inpatients with hypertension and coronary heart disease admitted to the People's Hospital of Xinjiang Uygur Autonomous Region from April 2019 to December 2021 were selected as the hypertension and coronary heart disease group.In addition,48 inpatients with simple hypertension admitted to our hospital during the same peri⁃od were selected as the simple hypertension group.Baseline data(age,gender,smoking,etc.)and laboratory test indicators[systolic blood pressure(SBP),diastolic blood pressure(DBP),triglyceride(TG),serum AngII,apoB/apoA⁃1,endocan,etc.]were collected from all patients.Univariate and multivariate logistic regres⁃sion were used to analyze the relationship between serum AngⅡ,apoB/apoA⁃1 combined with endocan and coronary heart disease in patients with hypertension.The ROC curve was further drawn to analyze the predic⁃tive value of serum AngⅡ,apoB/apoA⁃1,endocan alone and in combination for coronary heart disease in pa⁃tients with hypertension.Results There were significant differences during hypertension,LDL⁃C,serum AngⅡ,apoB,apoA⁃1,apoB/apoA⁃1 and endocan between the two groups(c2/t=4.044,4.093,2.908,2.699,2.629,4.528,4.244,P<0.05).Multivariate logistic regression analysis showed that the course of hypertension,LDL⁃C,serum AngⅡ,apoB/apoA⁃1 and endocan were independent risk factors for coronary heart disease in patients with hypertension(P<0.05).The ROC curve results showed that the area under the curve of serum AngⅡ,apoB/apoA⁃1 and endocan alone in predicting coronary heart disease in hypertensive patients was 0.692,0.713 and 0.701,respectively(P<0.05).The area under the curve of the combined detection of the three was the largest,0.831(P<0.05).Conclusion The risk of

关 键 词：血管紧张素Ⅱ 载脂蛋白B与载脂蛋白A⁃1比值 人血管内皮细胞特异性分子 高血压 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病] R544.1[医药卫生—内科学]