自噬对雄性哺乳动物生殖的影响  

Effect of autophagy on male mammalian reproduction

作　　者：薛振 李盼 杨玉菲 宁波 路宏朝[1,2,4] 王令[1,3,4] 马海东 张涛[1,2,4] XUE Zhen;LI Pan;YANG Yufei;NING Bo;LU Hongzhao;WANG Ling;MA Haidong;ZHANG Tao(School of Biological Science and Engineering,Shaanzi University of Technology,Hanzhong 72300l,China;Qinba State Key Laboratory of Biological Resources and Ecological Environment,Shaanri University of Technology,Hanzhong 72300l,China;Shaanci Province Key Laboratory of Bio-resources,Shaanri University of Technology,Hanzhong 723001,China;Qinling-Bashan Mountains Bioresources Comprehensive Development Co-Innovation Center,Shaanri University of Technology,Hanzhong 72300l,China)

机构地区：[1]陕西理工大学生物科学与工程学院,陕西汉中723001 [2]陕西理工大学秦巴生物资源与生态环境省部共建国家重点实验室(培育),陕西汉中723001 [3]陕西理工大学陕西省资源生物重点实验室,陕西汉中723001 [4]陕西理工大学陕南秦巴山区生物资源综合开发协同创新中心,陕西汉中723001

出　　处：《扬州大学学报（农业与生命科学版）》2023年第3期18-28,共11页Journal of Yangzhou University：Agricultural and Life Science Edition

基　　金：陕西省重点研发计划项目(2023-YBNY-138);陕西理工大学人才启动项目(SLGRCQD2005)。

摘　　要：自噬是细胞内蛋白质和细胞器降解与循环利用的一种分解代谢过程,参与细胞增殖与分化等各种生物学过程。大量研究表明,自噬与雄性生殖密切相关,特别是精子发生和睾酮分泌,但自噬对雄性生殖是保护还是损伤,以及相关的分子机制仍不清楚。梳理总结了自噬在精子生成和睾酮分泌过程中的作用,并分析了药物诱导自噬对雄性生殖的影响,为自噬相关疾病的治疗,特别是男性不育领域的研究提供了一定的借鉴与见解。Autophagy is an intracellular catabolic process of degrading and recycling proteins and organelles to modulate various physiological and pathological events,including cell differentiation and development.Emerging data indicate that autophagy is closely associated with male reproduction,especially the biosynthetic and catabolic processes of sperm and testosterone.Nonetheless,the most question of whether autophagy plays a protective or harmful role in male reproduction,remains unclear.This review summarizes the functional roles of autophagy in spermatogenesis and testosterone secretion.Additionally,critical mechanisms of the action and clinical impacts of autophagy on sperm and testosterone are identified.By explaining the role of autophagy in the overall fate of sperm and testosterone,this paper will provide valuable insights into the treatment of diseases,especially male infertility.

关 键 词：自噬 下丘脑-垂体-睾丸轴 精子发生 睾酮合成 

分 类 号：Q132.1[生物学—普通生物学]