钙纳米粒在肿瘤免疫治疗应用中的研究进展  

Research progress of calcium nanoparticles in tumor immunotherapy

作　　者：直炜炜 祝侠丽[1] 贾永艳[1] 胥芷灵 李一菁 黄胜楠 ZHI Wei-wei;ZHU Xia-li;JIA Yong-yan;XU Zhi-ling;LI Yi-jing;HUANG Sheng-nan(Pharmacy College,Henan University of Chinese Medicine,Zhengzhou 450046,China;Academy of Chinese Medical Sciences,Henan University of Chinese Medicine,Zhengzhou 450046,China;School of Pharmaceutical Sciences,Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases of Henan Province,Zhengzhou University,Zhengzhou 450001,China)

机构地区：[1]河南中医药大学药学院,郑州450046 [2]河南中医药大学中医药科学院,郑州450046 [3]郑州大学药学院,河南省肿瘤重大疾病靶向治疗和诊断重点实验室,郑州450001

出　　处：《中国新药杂志》2023年第12期1220-1227,共8页Chinese Journal of New Drugs

基　　金：国家自然科学基金项目(82003298);河南省博士后科研项目(201901025);河南省肿瘤重大疾病靶向治疗与诊断重点实验室开放基金项目(NMZL2020102);河南省科技攻关项目(232102310392);河南中医药大学科研创新项目(2022KYCX031)。

摘　　要：肿瘤免疫治疗因其可以利用患者的免疫系统根除肿瘤并防止复发,而成为一种极具潜力的肿瘤治疗方法。纳米粒因其独特的优势,有望成为实现肿瘤免疫治疗的最佳载体。钙离子(calcium ion,Ca^(2+))作为细胞内的第二信使,在调节体内免疫反应中发挥着重要作用。近些年的研究表明,钙纳米粒如过氧化钙(calcium peroxide,CaO_(2))纳米粒、磷酸钙(calcium phosphate,CaP)纳米粒、氢化钙(calcium hydride,CaH_(2))纳米粒和碳酸钙(calcium carbonate,CaCO_(3))纳米粒等,可以通过多种机制激活抗肿瘤免疫反应。此外,钙纳米粒还可以通过与其他疗法如光热疗法(phototherapy,PTT)、声动力疗法(sonodynamic therapy,SDT)、化学治疗和放射疗法等的联合使用,协同对抗肿瘤,发挥出“免疫+”的抗肿瘤效果。本文总结了近几年钙纳米粒在肿瘤免疫治疗中取得的研究进展,并对其面临的挑战进行了展望。Tumor immunotherapy holds immense potential for tumor treatment because it can utilize the patient's immune system to eradicate tumors and prevent tumor recurrence.Nanoparticles are expected to be the optimal carrier for tumor immunotherapy due to their unique advantages.Ca^(2+),as the second messenger in cells,plays an important role in regulating the immune response in vivo.Recent studies have shown that calcium nanoparticles,such as calcium peroxide(CaO_(2))nanoparticles,calcium phosphate(CaP)nanoparticles,calcium hydride(CaH_(2))nanoparticles and calcium carbonate(CaCO_(3))nanoparticles,can activate anti-tumor immune responses through a variety of mechanisms.In addition,calcium nanoparticles can also be used in combination with other therapies such as photothermal therapy(PTT),sonodynamic therapy(SDT),chemotherapy and radiotherapy to synergically fight tumors to exert the“immune+”anti-tumor effect.In this article,we reviewed the recent research progress of calcium nanoparticles in tumor immunotherapy,and looked forward to the challenges of this field.

关 键 词：钙纳米粒 肿瘤免疫治疗 联合疗法 免疫+ 

分 类 号：R944[医药卫生—药剂学]