儿童腺病毒肺炎免疫功能变化及免疫治疗的临床研究  

Clinical study on immune function changes and immunotherapy in children with adenovirus pneumonia

作　　者：陈方根 李苏宝 蓝欣 廖细生[1] CHEN Fanggen;LI Subao;LAN Xin;LIAO Xisheng(Department of Internal Medicine of Pediatric Infection,Jiangxi Provincial Children’s Hospital,Nanchang 330000,Jiangxi,China)

机构地区：[1]江西省儿童医院小儿感染内科,江西南昌330000

出　　处：《中国现代医生》2023年第20期18-21,共4页China Modern Doctor

基　　金：江西省卫生健康委科技计划(20203664)。

摘　　要：目的探究儿童腺病毒肺炎免疫功能变化及免疫治疗对其影响。方法回顾性选取2020年12月至2022年3月江西省儿童医院收治的26例腺病毒肺炎患儿作为病例组,选取同期就诊的25例上呼吸道感染患儿作为对照组。观察治疗前后病例组患儿外周血T淋巴细胞亚群(CD16^(+)CD56^(+)、CD4、CD8、CD19、CD4/CD8)、免疫球蛋白(immunoglobulin,Ig)(IgM、IgG、IgA、IgE)、补体(complement,C)(C3、C4)、相关细胞因子[白细胞介素(interleukin,IL)-2、IL-6、IL-10、肿瘤坏死因子-α(tumornecrosisfactor-α,TNF-α)]变化,并比较其与对照组的差异。结果治疗前,病例组的CD16^(+)CD56^(+)、CD4、CD19、CD4/CD8、IgG、IgA、C3、C4显著低于对照组(P<0.05),CD8、IL-2、IL-6、IL-10、TNF-α显著高于对照组(P<0.05);治疗后,病例组的CD8、CD4/CD8、IgG、IgA、C3、C4、IL-2、IL-6、IL-10、TNF-α显著高于对照组(P<0.05)。治疗后病例组的CD16^(+)CD56^(+)、CD4、CD19、CD4/CD8、IgG、IgA、C3、C4、IL-2、IL-6、IL-10、TNF-α均显著高于治疗前(P<0.05),CD8显著低于治疗前(P<0.05),IgM、IgE与治疗前比较,差异无统计学意义(P>0.05)。结论腺病毒肺炎可导致患儿免疫功能变化,免疫治疗有助于患儿免疫功能提升,控制患儿病情。Objective To explore the changes of immune function in children with adenovirus pneumonia and the effect of immunotherapy.Methods A total of 26 children with adenovirus pneumonia admitted to Jiangxi Provincial Children’s Hospital from December 2020 to March 2022 were selected as the case group,and 25 children with upper respiratory tract infection attending the same period were selected as the control group.The T-lymphocyte subsets(CD16^(+)CD56^(+),CD4,CD8,CD19,CD4/CD8),immunoglobulin(IgM,IgG,IgA,IgE),complement(C3,C4),and related cytokines[interleukin(IL)-2,IL-6,IL-10,tumor necrosis factor-α(TNF-α)]were observed in the case group before and after treatment,and the differences were compared with the control group.Results Before treatment,CD16^(+)CD56^(+),CD4,CD19,CD4/CD8,IgG,IgA,C3,C4 were significantly lower in the case group than those in the control group(P<0.05),and CD8,IL-2,IL-6,IL-10,TNF-αwere significantly higher in the case group than those in the control group(P<0.05).After treatment,CD8,CD4/CD8,IgG,IgA,C3,C4,IL-2,IL-6,IL-10,TNF-αwere significantly higher in the case group than those in the control group(P<0.05).After treatment,CD16^(+)CD56^(+),CD4,CD19,CD4/CD8,IgG,IgA,C3,C4,IL-2,IL-6,IL-10 and TNF-αwere significantly higher in the case group than pre-treatment(P<0.05),CD8 was significantly lower than pre-treatment(P<0.05),and IgM and IgE were not statistically significant when compared with pre-treatment(P>0.05).Conclusion Adenovirus pneumonia can lead to changes in immune function of children,and immunotherapy can help improve the immune function and control the disease condition of children.

关 键 词：儿童 腺病毒肺炎 免疫功能 免疫治疗 

分 类 号：R72[医药卫生—儿科]