体外冲击波联合滑膜炎颗粒治疗湿热痹阻型膝骨关节炎的临床疗效研究  

Clinical Efficacy of Extracorporeal Shock Wave Therapy and Synovitis Granules in the Treatment of Damp-heat Blocking Collateral Type of Knee Osteoarthritis

作　　者：梁晖[1] 周小锦 张意侗 解纪惠 刘世欢[1] 谢秋芳 张俊 梅宁宁 LIANG Hui;ZHOU Xiaojin;ZHANG Yitong(Department of Orthopaedics,Shijiazhuang Hospital of Traditional Chinese Medicine,Hebei 050051,China)

机构地区：[1]石家庄市中医院骨科,050051

出　　处：《医学研究杂志》2023年第7期118-123,共6页Journal of Medical Research

基　　金：河北省中医药管理局科研计划项目(2020341,2018215)。

摘　　要：目的研究体外冲击波联合滑膜炎颗粒治疗湿热痹阻型膝骨关节炎(knee osteoarthritis,KOA)的临床疗效。方法前瞻性研究2020年9月~2021年8月就诊于石家庄市中医院骨科门诊的70例KOA患者,按照随机数字表法将其分为对照组和治疗组,每组各35例。对照组患者给予滑膜炎颗粒治疗,治疗组患者给予体外冲击波联合滑膜炎颗粒治疗,治疗4周后,对两组患者的血清炎性指标[C反应蛋白(C reactive protein,CRP)、白细胞介素(interleukin,IL)-1、IL-6、IL-8]、疼痛视觉模拟量表(visual analog scale,VAS)评分、西大略和麦克马斯特大学骨关节炎指数(The Western Ontario and McMaster Universities Osteoarthritis Index,WOMAC)评分、肿胀程度、中医证候评分等进行比较。结果最终纳入KOA患者65例,其中对照组33例,治疗组32例。治疗后,两组患者的VAS评分、WOMAC评分、中医证候评分、CRP、IL-1、IL-6、IL-8较治疗前均降低(P<0.05);治疗后,治疗组患者的WOMAC评分、中医证候评分、膝关节肿胀程度、CRP、IL-1、IL-6、IL-8均低于对照组,差异有统计学意义(P<0.05)。结论体外冲击波联合滑膜炎颗粒治疗KOA,可以明显缓解疼痛,改善关节功能,减轻关节肿胀,降低炎性细胞因子。Objective To investigate the clinical efficacy of extracorporeal shock wave therapy combined with synovitis particles in the treatment of damp-heat blocking collateral type knee osteoarthritis(KOA).Methods Seventy patients with KOA were selected from the Department of Orthopedics,Shijiazhuang Hospital of Traditional Chinese Medicine from September 2020 to August 2021.According to the random number table method,they were divided into control group and treatment group,35 cases in each group.The control group was treated with synovitis granules,the treatment group was treated with extracorporeal shock wave therapy combined with synovitis granules.Four weeks after treatment,serum inflammatory markers[C reactive protein(CRP),interleukin(IL)-1,IL-6,IL-8],visual analog scale(VAS)score,the Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score,degree of knee swelling and TCM syndrome score between the two groups were compared.Results Finally,65 KOA patients were included,including 33 in the control group and 32 in the treatment group.After treatment,VAS score,WOMAC,TCM syndrome score,CRP,IL-1,IL-6,IL-8 in both groups decreased compared with before treatment(P<0.05);After treatment,WOMAC score,TCM syndrome score,degree of knee swelling,CRP,IL-1,IL-6,IL-8 of the treatment group was lower than the control group,which was statistically significant(P<0.05).Conclusion Extracorporeal shock wave therapy combined with synovitis particles for KOA can significantly relieve pain,improve joint function,reduce joint swelling and reduce inflammatory factors.

关 键 词：体外冲击波 滑膜炎颗粒 湿热痹阻 膝骨关节炎 临床疗效 

分 类 号：R274.9[医药卫生—中西医结合]