D-dimer及hsCRP变化与主动脉夹层患者结局关系  

Correlation of changes in D-dimer and high-sensitivity C-reactive protein levels with the outcome of aortic dissection

作　　者：陈慧[1] 张曼莉[1] 赵昆[1] 尹化 聂德正 佟飞[1] CHEN Hui;ZHANG Manli;ZHAO Kun(Department of Critical Care Medicine,the Second Hospital of Hebei Medical University,Hebei,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院重症医学科,石家庄市050000

出　　处：《河北医药》2023年第14期2145-2148,共4页Hebei Medical Journal

基　　金：河北省医学科学研究重点课题计划(编号:20211697)。

摘　　要：目的探讨D-dimer及超敏C-反应蛋白(hs-CRP)变化趋势与主动脉夹层患者结局之间关系。方法收集2019年1月到2020年6月急诊科就诊并确诊为主动脉夹层的患者50例,记录其年龄、性别、结局,以及入院时和入院48 h后的D-dimer及hsCRP水平,分析其变化趋势与结局之间的关系。结果共有50患者纳入研究,其中10例患者死亡,死亡组与存活组入院时的D-dimer水平比较,差异无统计学意义(P>0.05),而入院时的死亡组hs-CRP水平、入院48 h后的D-dimer及hsCRP水平均显著高于存活组(P<0.05);死亡组患者入院48 h后的D-dimer及hsCRP水平均较入院时显著升高(P<0.05);而存活组入院48 h后的D-dimer水平较入院时明显下降(P<0.01)。结论死亡组患者的D-dimer及hsCRP均呈上升趋势,临床应注意动态监测患者的D-dimer及CRP变化,以早期分辨高危患者,及时采取相应治疗措施。Objective To identify the correlation of changes in D-dimer and high-sensitivity C-reactive protein(hsCRP)levels with the outcome of aortic dissection.Methods A total of 50 patients diagnosed as aortic dissection and treated in the emergency department of our hospitalfrom January 2019 to June 2020 were recruited.Their age,gender,outcome,D-dimer and hsCRP levels on admission and 48 hours after admission were recorded,and the correlation of changes in D-dimer and hsCRP with the outcome was analyzed.Results A total of 50 patients were included in the study,including 10 deaths(death group)and 40 survivers(survival group).There was no significant difference in the D-dimer level on admission between the death group and the survival group(P>0.05),while hsCRP level on admission,and D-dimer and hsCRP levels at 48 hours after admission in death group were significantly higher than those in the survival group(P<0.05).D-Dimer and hsCRP levels in the death group at 48 hours after admission were significantly higher than those on admission(P<0.05).D-dimer level at 48 hours after admission in survival group was significantly lower than that on admission(P<0.01).Conclusion D-dimer and hsCRP levels increase in died patients with aortic dissection.Their levels should be dynamically monitored in patients with aortic dissection,thus discriminating high-risk population in the early stage and providing clinical management.

关 键 词：D-二聚体 HS-CRP 主动脉夹层 预后 临床分型 

分 类 号：R543.1[医药卫生—心血管疾病]