黄连主要活性成分及药理作用研究进展  

Research progress on active constituents and pharmacological effect of Coptidis Rhizoma

作　　者：刘晓龙 李春燕[1,2] 肖先 薛金涛 LIU Xiaolong;LI Chunyan;XIAO Xian;XUE Jintao(College of Pharmacy,Xinxiang Medical University,Xinxiang 453003,Henan Province,China;Biological and Basic Medical Experimental Teaching Center,Sanquan College of Xinxiang Medical University,Xinxiang 453003,Henan Province,China)

机构地区：[1]新乡医学院药学院,河南新乡453002 [2]新乡医学院三全学院生物与基础医学实验教学中心,河南新乡453003

出　　处：《新乡医学院学报》2023年第8期784-790,共7页Journal of Xinxiang Medical University

基　　金：河南省重点研发与推广专项(河南省科技攻关计划)(编号:222102310566)。

摘　　要：黄连为毛茛科植物黄连、三角叶黄连或云连的干燥根茎。黄连含有生物碱类、木脂素类、黄酮类、酸性成分和挥发油类等多种化学成分,其中最主要的成分是黄连素,又称小檗碱。黄连味苦、性寒,具有清热燥湿、泻火解毒的作用,常用于治疗呕吐吞酸、泻痢、消渴、痈肿疔疮,外治湿疹、湿疮、耳道流脓等。现代药理学研究表明,黄连具有抗心律失常、抗肿瘤、降血糖、抗炎等多种药理作用。本文就黄连的主要活性成分和药理作用进行综述,以期为黄连的开发和临床利用提供参考依据。Coptidis Rhizoma is the dry rhizome of Coptis chinensis Franch.,Coptis deltoidea C.Y.Cheng et Hsiao or Coptis teeta Wall.of Ranunculaceae.Coptidis Rhizoma contains many chemical components such as alkaloids,lignans,flavonoids,acidic components and volatile oil,among which the most important component is berberine,also known as Berberine Hydrochloride.Coptidis Rhizoma has a bitter taste and a cold nature,and has the effects of clearing heat,drying dampness,purging fire,and detoxifying;it was commonly used to treat vomiting,acid swallowing,diarrhea,thirst,carbuncle and boils,external treatment of eczema,wet sores,ear canal pus,etc.Modern pharmacological research has shown that Coptidis Rhizoma has various pharmacological effects such as anti-arrhythmia,anti-tumor,hypoglycemic,anti-inflammatory,etc.This article reviews the main active constitutents and pharmacological effects of Coptidis Rhizoma,in order to provide reference for the development and clinical application of Coptidis Rhizoma.

关 键 词：黄连 化学成分 药理作用 

分 类 号：R932[医药卫生—生药学]