畸形精子症发生的分子机制研究进展  

Research progress on the molecular mechanism of teratozoospermia

作　　者：杨旭辉[1] 汪惠琴[1] 朱照平[1] 吴远菲[1] YANG Xuhui;WANG Huiqin;ZHU Zhaoping;WU Yuanfei(Department of Reproductive Health and Infertility,Guangdong Women and Children′s Hospital,Guangzhou 510080,Guangdong Province,China)

机构地区：[1]广东省妇幼保健院生殖健康与不孕症科,广东广州510080

出　　处：《新乡医学院学报》2023年第8期796-800,共5页Journal of Xinxiang Medical University

摘　　要：畸形精子症是导致男性不育的重要因素之一,其病因和发病机制至今尚不清楚。近些年的研究显示,一些基因与畸形精子症的发生相关。为了明确畸形精子症的病因,更好地理解畸形精子症的发病机制,让临床医生能够为患者提供遗传咨询、诊断策略和最佳的治疗方案,本文就特殊类型的畸形精子症如圆头精子症、大精子症、无头精子症、鞭毛多发形态异常等相关的基因及分子机制进行综述。Teratozoospermia is one of the important factors leading to male infertility,and its pathogenesis is not yet clear.Recent researches have shown that some genes are related to the occurrence of spermatogenesis.In order to clarify the cause of teratozoospermia,better understand the pathogenesis of teratozoospermia,and enable clinicians to provide genetic counseling,diagnostic strategies and the best treatment scheme for patients.This article reviews the genes and molecular mechanisms related to special types of teratozoospermia such as globozoospermia,macrozoospermia,cephalospermia and multiple morphological abnormality of flagellum.

关 键 词：畸形精子症 圆头精子症 大精子症 

分 类 号：R698[医药卫生—泌尿科学]