抑制补体激活在脓毒症相关性凝血功能障碍治疗中作用的研究进展  

Advances in the effect of inhibiting complement activation in the treatment of sepsis-associated coagulopathy

作　　者：卢鑫 魏昕[2] 王志斌 Lu Xin;Wei Xin;Wang Zhibin(Department of Critical Care Medicine,School of Anesthesiology,Naval Medical University,Shanghai 200433,China;Department of Clinical Pharmacy,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200092,China)

机构地区：[1]海军军医大学麻醉系危重病医学教研室,上海200433 [2]上海交通大学医学院附属新华医院临床药学部,上海200092

出　　处：《中华危重病急救医学》2023年第4期438-441,共4页Chinese Critical Care Medicine

基　　金：国家自然科学基金(81872880,82104269)。

摘　　要：脓毒症相关性凝血功能障碍特指全身广泛的凝血激活,并伴随极高的出血风险及器官功能衰竭的发生风险,严重时表现为弥散性血管内凝血(DIC),并导致多器官功能障碍综合征(MODS)。补体是机体固有免疫系统的重要组成部分,在抵御外界病原微生物入侵时发挥重要作用。脓毒症的早期病理过程中就涉及补体系统的过度激活,并且通过与凝血系统、激肽系统和纤溶系统之间的相互作用,在体内形成极为复杂的网络,扩大和加剧全身炎症反应。近年来有研究者指出,补体系统异常激活可加剧脓毒症导致的凝血功能障碍甚至造成DIC,提示干预补体系统在脓毒症DIC治疗中具有潜在价值,本文就其相关研究进展进行综述,以期为脓毒症相关性凝血功能障碍治疗药物的研发提供新思路。Sepsis-associated coagulopathy refers to extensive coagulation activation accompanied by a high risk of bleeding and organ failure.In severe cases,it is manifested as disseminated intravascular coagulation(DIC)and leads to multiple organ dysfunction syndrome(MODS).Complement is an important component of the innate immune system and plays an important role in defending against invasion of pathogenic microorganisms.The early pathological process of sepsis involves excessive activation of the complement system,which forms an extremely complex network through interactions with the coagulation,kinin and fibrinolytic system,amplifying and exacerbating the systemic inflammatory response.In recent years,it has been suggested that uncontrolled complement activation system can exacerbate sepsis-associated coagulation dysfunction or even DIC,indicating the potential value of intervening in the complement system in the treatment of septic DIC,and related research progress is reviewed in this article in order to provide new ideas for the discovery of sepsis-associated coagulopathy therapy drugs.

关 键 词：脓毒症 凝血功能障碍 弥散性血管内凝血 补体 

分 类 号：R459.7[医药卫生—急诊医学]