布地奈德、沙丁胺醇联合α1b干扰素雾化治疗喘息性支气管炎患儿的临床效果  

Clinical Effect of Budesonide,Salbutamol,andα1b Interferon Nebulization in the Treatment of Children with Asthmatic Bronchitis

作　　者：郭医妍 郝晓阳 GUO Yiyan;HAO Xiaoyang(Beijing Shijingshan Hospital,Beijing 100043,China;不详)

机构地区：[1]北京市石景山医院,北京100043

出　　处：《中外医学研究》2023年第20期26-30,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨布地奈德、沙丁胺醇联合α1b干扰素雾化治疗喘息性支气管炎患儿的临床效果。方法:抽取2019年10月—2023年1月北京市石景山医院收治的喘息性支气管炎住院患儿150例为研究对象,采用完全双盲法将患儿分为对照组和试验组,各75例。对照组行布地奈德+沙丁胺醇雾化治疗,试验组行布地奈德+沙丁胺醇+α1b干扰素雾化治疗,两组均治疗1周。观察两组治疗前后肺功能指标、免疫功能指标变化情况,比较两组治疗效果、症状及体征消失时间及用药安全性。结果:治疗1周后,两组潮气量(TV)、潮气呼吸呼气峰流速(PTEF)、吸气呼气时间比(TI/TE)均显著优于治疗前,且试验组上述各项指标均显著优于对照组,差异有统计学意义(P<0.05)。治疗1周后,两组CD3^(+)、CD4^(+)/CD8^(+)均显著高于治疗前,且试验组上述各免疫功能指标均显著高于对照组,差异有统计学意义(P<0.05)。试验组治疗总有效率显著高于对照组,差异有统计学意义(P<0.05)。试验组退热时间、喘憋消失时间、咳嗽消失时间、咳痰消失时间及哮鸣音消失时间均早于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:针对喘息性支气管炎患儿,予以布地奈德+沙丁胺醇+α1b干扰素雾化治疗,可改善患儿肺功能及免疫功能,减轻不适症状,促进患儿康复,且安全性好。Objective:To explore the clinical effect of Budesonide,Salbutamol andα1b Interferon nebulization in the treatment of children with asthmatic bronchitis.Method:A total of 150 hospitalized children with asthmatic bronchitis admitted to Beijing Shijingshan Hospital from October 2019 to January 2023 were selected as the study subjects,and the children were divided into control group and test group by a completely double-blind method,with 75 cases in each group.The control group was treated with Budesonide+Salbutamol atomization,and the test group was treated with Budesonide+Salbutamol+α1b Interferon atomization.Both groups were treated for one week.Observed the changes in lung function and immune function indicators before and after treatment in two groups,and compared the treatment effect,sympotom and sign disappearance time,and medication safety between the two groups.Result:After one week of treatment,the tidal volume(TV),peak tidal expiratory flow(PTEF),the ratio of inspiratory time and expiratory time(TI/TE)of the two groups were significantly better than those before treatment,and the above indicators of the test group were significantly better than those of the control group,the differences were statistically significant(P<0.05).After one week of treatment,the levels of CD3^(+)and CD4^(+)/CD8^(+)in both groups were significantly higher than those before treatment,and the above immune function indicators in the test group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of treatment in the test group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).The test group had earlier fever relief time,disappearance time of wheezing,cough,phlegm,and wheezing than the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:For

关 键 词：喘息性支气管炎 布地奈德 沙丁胺醇 Α1B干扰素 雾化 效果 

分 类 号：R725.6[医药卫生—儿科]