非肌肉肌球蛋白ⅡA型在肿瘤转移中的研究进展  

Research progress of NMIIA in tumor metastas

作　　者：曲继强 任彦霖 纪文卉 夏明钰[1] QU Jiqiang;REN Yanlin;JI Wenhui;XIA Mingyu(School of Life Science and Biopharmaceutics,Shenyang Pharmaceutical University,shenyang 110016,China)

机构地区：[1]沈阳药科大学生命科学与生物制药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2023年第6期799-806,共8页Journal of Shenyang Pharmaceutical University

基　　金：辽宁省自然科学基金资助项目(20180550820)。

摘　　要：目的对现有的非肌肉肌球蛋白ⅡA型(NMIIA)对肿瘤转移中的作用现状进行综述,为NMIIA在肿瘤转移中的相关研究提供理论基础。方法检索相关文献,深入总结NMIIA在肿瘤细胞中转移的专用机制。结果NMIIA是一种细胞膜骨架的重要组成蛋白,又可与肌动蛋白共同作用使细胞发生运动。近年来研究发现,NMIIA的表达与多种癌症的恶性程度密切相关,在肿瘤转移中发挥作用,其中NMIIA可受ROCK、NudCL2、TFPI-2和S100A4等上游蛋白调控,进而影响AKT/mTOR、F-actin等蛋白功能,同时NMIIA也可以调节线粒体分裂,参与EMT进程促进肿瘤转移。结论基于已有的文献总结,我们发现NMIIA在肿瘤转移中起重要作用并且作用机制复杂,NMIIA是解决肿瘤转移的重要研究方向之一。Objective To review the current status of the role of non muscle myosin IIA(NMIIA)in tumor metastasis and provide a theoretical basis for the related research of NMIIA in tumor metastasis.Methods Retrieve relevant literature and thoroughly summarize the specific mechanism of NMIIA metastasis in tumor cells.Results NMIIA is an important component protein of cell membrane skeleton,and it can work together with actin to make cells move.In recent years,it has been found that the expression of NMIIA is closely related to the malignancy of many cancers and plays a role in tumor metastasis.NMIIA can be regulated by upstream proteins such as ROCK,NudCL2,TFPI-2 and S100A4,thereby affecting protein functions such as AKT/mTOR and F-actin.At the same time,NMIIA can also regulate mitochondrial fission and participate in the EMT process to promote tumor metastasis.Conclusion Based on the summary of existing literature,we found that NMIIA plays an important role in tumor metastasis and its mechanism of action is complex.NMIIA is one of the important research directions for solving tumor metastasis.

关 键 词：非肌肉肌球蛋白ⅡA型 AKT/MTOR S100A4 NudCL2 ROCK TFPI-2 线粒体分裂 EMT 肿瘤转移 

分 类 号：R96[医药卫生—药理学]