韦氏三联九针治疗糖尿病性眼肌麻痹的疗效及对血液流变学的影响  

Effect of WEI's Triple Nine-needle Therapy on Diabetic Ophthalmoplegia and Its Im⁃pact on Hemorheology

作　　者：冯坤 王文 彭一 韩克阳 FENG Kun;WANG Wen;PENG Yi;HAN Keyang(Zaozhuang Hospital of Traditional Chinese Medicine,Zaozhuang 277101,China)

机构地区：[1]山东省枣庄市中医医院,枣庄277101

出　　处：《中国中医眼科杂志》2023年第8期732-736,761,共6页China Journal of Chinese Ophthalmology

基　　金：山东省中医药科技项目(2020Q084)。

摘　　要：目的探讨韦氏三联九针治疗糖尿病性眼肌麻痹的疗效和血液流变学的影响。方法纳入2021年1月—2022年3月枣庄市中医医院眼科收治的糖尿病性眼肌麻痹患者100例,以随机数表法分为治疗组和对照组,每组各50例(50只眼)。对照组患者行降糖、控制饮食、营养神经等常规治疗,治疗组在对照组的基础上给予韦氏三联九针治疗,2组均治疗15 d。分别于治疗前、后检测患者的平均斜视角、血液流变学[血浆纤维蛋白原(FIB)、红细胞聚集指数(RBCAI)、全血黏度(BV)、红细胞沉降(ESR)及血浆黏度(PV)]、血清同型半胱氨酸(Hcy)、胱抑素C(CysC)及缺氧诱导因子-1α(HIF-1α)水平及临床疗效。结果2组治疗前平均斜视角、血液流变学水平及Hcy、CysC及HIF-1α水平比较,差异均无统计学意义(P>0.05)。(1)平均斜视角:2组治疗后平均斜视角均较治疗前降低,差异均有统计学意义(t_(治疗组)=14.943,t_(对照组)=9.013,均P=0.000)。治疗后2组间比较,治疗组较对照组降低,差异有统计学意义(t=5.712,P=0.000)。(2)血液流变学:2组治疗后FIB(t_(治疗组)=17.239,t_(对照组)=11.205,均P=0.000)、RBCAI(t_(治疗组)=5.828,P=0.000;t_(对照组)=3.545,P=0.001)、BV(t_(治疗组)=6.029,P=0.000;t_(对照组)=3.354,P=0.001)、ESR(t_(治疗组)=19.640,t_(对照组)=10.874,均P=0.000)及PV(t_(治疗组)=8.122,t_(对照组)=4.608,均P=0.000)均较治疗前降低,差异均有统计学意义。治疗后2组间比较,治疗组均较对照组降低(t_(FIB)=6.476,P=0.000;t_(RBCAI)=2.932,P=0.004;t_(BV)=2.952,P=0.003;t_(ESR)=12.817,P=0.000;t_(PV)=3.667,P=0.000),差异均有统计学意义。(3)Hcy、CysC及HIF-1α水平:2组治疗后Hcy(t_(治疗组)=11.495,P=0.000;t_(对照组)=2.702,P=0.009)、CysC(t_(治疗组)=8.120,P=0.000;t_(对照组)=2.941,P=0.005)及HIF-1α(t_(治疗组)=7.174,P=0.000;t_(对照组)=3.376,P=0.001)水平均较治疗前降低,差异有统计学意义。治疗后2组间比较,治疗组均较对照组降低(t_(Hcy)OBJECTIVE To investigate the impact of WEI´s Triple Nine-needle Therapy on hemorheology in patients with diabetic ophthalmoplegia.METHODS A total of 100 patients with diabetic ophthalmoplegia,treated at the Department of Ophthalmology,Zaozhuang Hospital of Traditional Chinese Medicine from January 2021 to March 2022,were included and randomly divided into a treatment group and a control group,with 50 patients in each group(50 eyes).The control group received conventional treatments such as glycemic control,dietary control,and nutritional support.In addition to the conventional treatments,the treatment group received WEI´s Triple Nine-needle Therapy.Both groups were treated for 15 days.Before and after the treatment,the average strabismus angle,hemorheological parameters(plasma fibrinogen,red blood cell aggregation index,whole blood viscosity,erythrocyte sedimentation rate,and plasma viscosity),serum homocysteine(Hcy),cystatin C(CysC),and hypoxia-inducible factor-1α(HIF-1α)levels were measured,and clinical efficacy was evaluated.RESULTS There were no significant differences in the average strabismus angle,hemorheological parameters,Hcy,CysC,and HIF-1αlevels between the two groups.(1)Average strabismus angle:After treatment,both groups showed a significant reduction in the average strabismus angle compared to before treatment(t_(TG)=14.943,t_(CG)=9.013,both P=0.000).The treatment group had a significantly lower average strabismus angle compared to the control group after treatment(t=5.712,P=0.000).(2)Hemorheological parameters:The hemorheological parameters including fibrinogen(FIB),red blood cell aggregation index(RBCAI),blood viscosity(BV),erythrocyte sedimentation rate(ESR),and plasma viscosity(PV)were significantly reduced in both groups after treatment(TG:t_(FIB)=17.239,t_(RBCAI)=5.828,t_(BV)=6.029,all P=0.000;t_(ESR)=19.640,t_(PV)=8.122,all P=0.000;CG:t_(FIB)=11.205,all P=0.000;t_(RBCAI)=3.545,P=0.001;t_(BV)=3.354,P=0.001;t_(ESR)=10.874,P=0.000;t_(PV)=4.608,P=0.000).The treatment group had significantly

关 键 词：韦氏三联九针 糖尿病性眼肌麻痹 针刺治疗 血液流变学 

分 类 号：R276.7[医药卫生—中医五官科学]