双唑泰栓剂治疗混合性阴道炎的临床效果  

Clinical Effect of Diazolide Suppository in the Treatment of Mixed Vaginitis

作　　者：刘丽丽[1] 朱橙星 李敏[3] LIU Li-Li;ZHU Cheng-Xing;LI Min(Department of Gynecology,Women's and Children's Hospital of Hainan Medical College,Haikou 570216,China;Department of Gynecology,Women's and Children's Hospital of Ningxia Medical University,Yinchuan 750003,China;Department of Gynecology,Women's and Children's Hospital of Qinghai University,Sining 810016,China)

机构地区：[1]海南医学院附属妇女儿童医院妇科,海口570216 [2]宁夏医科大学附属妇女儿童医院妇科,银川750003 [3]青海大学附属妇女儿童医院妇科,西宁810016

出　　处：《中国药物经济学》2023年第6期39-42,51,共5页China Journal of Pharmaceutical Economics

摘　　要：目的 探讨双唑泰栓剂与硝呋太尔制霉素阴道栓和硝呋太尔制霉素阴道软胶囊治疗混合性阴道炎的临床效果,为混合型阴道炎的规范化治疗提供依据。方法 选取2021年1月至2022年3月于海南医学院附属妇女儿童医院、宁夏医科大学附属妇女儿童医院、青海大学附属妇女儿童医院门诊就诊的360例混合性阴道炎女性患者作为研究对象。采用前瞻性、双盲、随机、平行对照方法,将患者分为对照A组、对照B组、观察组,每组120例。观察组应用双唑泰栓剂治疗,对照A组使用硝呋太尔制霉素阴道栓治疗,对照B组采用硝呋太尔制霉素阴道软胶囊治疗。比较3组患者的治疗效果。结果 观察组转阴率、总有效率高于对照A组、对照B组,差异有统计学意义(P<0.05);治疗后,观察组白日瘙痒,分泌物,充血、水肿,抓痕、皲裂、糜烂评分均低于对照A组和对照B组,差异有统计学意义(P<0.05);治疗后,观察组Ⅰ度阴道清洁患者占比高于对照A组和对照B组,Ⅲ度阴道清洁患者占比低于对照A组和对照B组,差异有统计学意义(P<0.05);随访6个月,观察组、对照A组、对照B组复发率分别为7.50%(9/120)、20.83%(25/120)和14.17%(17/120),差异有统计学意义(P<0.05);3组均无严重不良反应发生,不良反应发生率比较差异有统计学意义(P<0.05);观察组药物外漏情况满意率、用药满意率、白日瘙痒控制率均高于对照A组和对照B组,差异有统计学意义(P<0.05)。结论 在混合性阴道炎治疗中,双唑泰栓剂能够取得较硝呋太尔制霉素阴道栓和硝呋太尔制霉素阴道软胶囊更好的临床治疗效果,且可降低复发率和不良反应发生率,提高患者依从性。Objective To explore the clinical effect of Shuangzotai suppository,nifurtel nystatin vaginal suppository and nifurtel nystatin vaginal soft capsule in the treatment of mixed vaginitis,and to provide basis for the standardized treatment of mixed vaginitis.Methods A total of 360 female patients with mixed vaginitis were selected from January 2021 to March 2022 in the outpatient department of Women and Children's Hospital Affiliated to Hainan Medical College,Women and Children's Hospital Affiliated to Ningxia Medical University and Women and Children's Hospital Affiliated to Qinghai University.The patients were divided into control group A,control group B and observation group with 120 cases in each group using a prospective,double-blind,random and parallel control method.Observation group was treated with dizoltec suppository,control group A was treated with nifuratel to mycin vaginal suppository,control group B was treated with nifuratel to mycin vaginal softgel.The therapeutic effect of 3 groups was compared.ResultsThe negative conversion rate and total effective rate in observation group were higher than those in control group A and control group B,and the difference was statistically significant(P<0.05).After treatment,the scores of pruritus,secretion,congestion,edema,scratch,chapping and erosion in observation group were lower than those in control group A and control group B,with statistical significance(P<0.05).After treatment,the proportion of patients with degree I vaginal cleanliness in observation group was higher than that in control group A and control group B,and the proportion of patients with degree II vaginal cleanliness was lower than that in control group A and control group B,the difference was statistically significant(P<0.05).After 6 months of follow-up,the recurrence rates of observation group,control group A and control group B were 7.50%(9/120),20.83%(25/120)and 14.17%(17/120),respectively,and the difference was statistically significant(P<0.05).No serious adverse reactions occurred in the

关 键 词：混合性阴道炎 双唑泰栓剂 硝呋太尔制霉素阴道栓 硝呋太尔制霉素阴道软胶囊 

分 类 号：R711.31[医药卫生—妇产科学] R984[医药卫生—临床医学]