糖尿病合并泌尿系统感染患者酮症酸中毒危险因素分析  

Risk Factors of Ketoacidosis in Patients with Diabetes Complicated with Urinary Tract Infection

作　　者：周虹 谢飞 吉顺莉[2] 徐建华 ZHOU Hong;XIE Fei;JI Shun-Li;XU Jian-Hua(Pharmacy Department of Hai'an People's Hospital,Nantong 226600,China;Pharmacy Department of Nantong University Affiliated Hospital,Nantong 226001,China)

机构地区：[1]海安市人民医院药剂科,江苏南通直226600 [2]南通大学附属医院药学部,江苏南通226001

出　　处：《中国药物经济学》2023年第6期59-62,共4页China Journal of Pharmaceutical Economics

摘　　要：目的 探讨糖尿病合并泌尿系统感染患者酮症酸中毒(DKA)情况,分析糖尿病合并泌尿系统感染患者发生DKA的危险因素。方法 回顾性分析2021年1—12月海安市人民医院收治的60例糖尿病合并泌尿系统感染患者的临床资料,根据是否合并DKA分为DKA感染组和非DKA感染组。比较两组患者的临床资料和实验室检查结果,并进行多因素Logistic回归分析糖尿病合并泌尿系统感染患者发生DKA的危险因素。结果 单因素分析显示两组患者年龄、白细胞计数(WBC)、中性粒细胞百分比(N)、C反应蛋白(CRP)、白细胞介素-6(IL-6)、降钙素原(PCT)、尿WBC及尿培养结果差异有统计学意义(P<0.05);多因素Logistic回归分析显示年龄≥65岁、PCT≥0.5ng/L、尿WBC≥28个/ul、尿培养阳性是糖尿病合并泌尿系统感染患者发生DKA的危险因素。结论 糖尿病合并泌尿系统感染患者中,年龄≥65岁、PCT≥0.5 ng/L、尿WBC≥28个/ul、尿培养阳性的患者发生DKA风险更高,临床工作者应加强对糖尿病合并泌尿系统感染患者DKA高危因素的识别,以便及时准确地给予针对性干预措施。Objective To explore the situation of ketoacidosis(DKA) in diabetic patients with urinary tract infection,and to analyze the risk factors of DKA in diabetic patients with urinary tract infection.Methods Clinical data of 60 patients with diabetes mellitus combined with urinary tract infection admitted to Hai'an People's Hospital from January 2021 to December 2021 were retrospectively analyzed.They were divided into DKA infection group and non-DKA infection group according to whether they were combined with ketoacidosis.The clinical data and laboratory test results of the two groups were compared,and the risk factors of DKA in diabetic patients with urinary system infection were analyzed by multivariate Logistic regression.Results Univariate analysis showed that there were significant differences in age,white blood cell count(WBC),percentage of neutrophils(N),C-reactive protein(CRP),interleukin-6(IL-6),procalcitonin(PCT),urinary WBC and urine culture results between 2 groups(P<0.05).Multivariate Logistic regression analysis showed that age ≥65 years old,PCT≥0.5 ng/L,urinary WBC≥28/ul,and positive urine culture were risk factors for DKA in patients with diabetes complicated with urinary system infection.Conclusion In patients with diabetes mellitus complicated with urinary tract infection,patients with age ≥65 years old,PCT ≥0.5 ng/L,urinary WBC ≥28/ul,and positive urine culture have a higher risk of DKA.Clinical workers should strengthen the identification of high risk factors for DKA in patients with diabetes mellitus complicated with urinary tract infection,so as to give timely and accurate targeted intervention measures.

关 键 词：糖尿病 泌尿系统感染 酮症酸中毒 危险因素 

分 类 号：R587.2[医药卫生—内分泌] R691.3[医药卫生—内科学]