糖尿病合并肺结核耐药患者的危险因素分析  

Risk factors of drug resistance in diabetes mellitus complicated by pulmonary tuberculosis

作　　者：柴春维 石亮[1] 白永忠 董立明 乔荣 张晶 段慧萍 Chai Chunwei;Shi Liang;Bai Yongzhong;Dong Liming;Qiao Rong;Zhang Jing;Duan Huiping(First Department of Internal Medicine,Taiyuan Fourth People's Hospital,Taiyuan 030053,Shaanxi Province,China)

机构地区：[1]太原市第四人民医院内一科,太原030053

出　　处：《中国基层医药》2023年第7期979-982,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：山西省卫生健康委员会科研课题计划(2020106)。

摘　　要：目的探讨分析糖尿病合并肺结核耐药患者的危险因素。方法收集太原市第四人民医院2020年3月至2022年3月收治的糖尿病合并肺结核患者83例的临床资料,依据药物敏感试验结果分为敏感组(45例)和耐药组(38例)。采用单因素和多因素非条件logistic回归分析耐药的影响因素。结果单因素分析显示,两组血CD4^(+)T淋巴细胞计数降低(χ^(2)=11.73,P=0.001)、糖尿病并发症(χ^(2)=4.94,P=0.026)差异有统计学意义。以血CD4+T淋巴细胞计数是否低于平均值、糖尿病患者是否伴并发症为自变量,是否耐药为因变量,进行多因素非条件logistic回归分析,结果显示血CD4^(+)T淋巴细胞计数降低OR(95%CI)值为4.909(1.926~12.514),是糖尿病合并肺结核耐药患者的独立危险因素。结论血CD4+T淋巴细胞计数降低为糖尿病合并肺结核耐药患者的危险因素,临床中应早期干预。Objective To investigate the risk factors of diabetes mellitus complicated by pulmonary tuberculosis.Methods The clinical data of 83 patients with diabetes mellitus complicated by pulmonary tuberculosis who received treatment in Taiyuan Fourth People's Hospital from March 2020 to March 2022 were collected.These patients were divided into sensitive group(n=45)and resistant group(n=38)according to the results of drug sensitivity test.Univariate and multivariate non-conditional logistic regression was performed to analyze the influential factors of drug resistance.Results Univariate logistic regression results revealed that there were significant differences in blood CD4+T lymphocyte count(χ^(2)=11.73,P=0.001)and diabetic complications(χ^(2)=4.94,P=0.026).Multivariate non-conditional logistic regression analysis was performed taking whether blood CD4^(+)T lymphocyte count was lower than the average level and whether patients with diabetes mellitus had complications as independent variables,and taking whether drug resistance was a dependent variable.The results showed that the OR(95%CI)value of the decreased blood CD4^(+)T lymphocyte count was 4.909(1.926-12.514).It is a risk factor for drug resistance of diabetes mellitus complicated by pulmonary tuberculosis.Conclusion The decrease of blood CD4^(+)T lymphocyte count is a risk factor of drug resistance in diabetes mellitus complicated by pulmonary tuberculosis,and it should be intervened early in the clinic.

关 键 词：糖尿病 2型 结核 肺 广泛耐药结核 疾病特征 危险因素 T淋巴细胞 糖尿病并发症 回归分析 

分 类 号：R587.2[医药卫生—内分泌] R521[医药卫生—内科学]