ACPA阴性类风湿关节炎生物标志物相关研究进展  

Research progress on biomarkers related to ACPA-negative rheumatoid arthritis

作　　者：章懿 周胜利[1,2] Zhang Yi;Zhou Shengli(Traditional Chinese Medicine Department of Rheumatology,The Second People's Hospital of Hefei,Hefei 230011,Anhui Province,China)

机构地区：[1]合肥市第二人民医院中医,合肥230011 [2]合肥市第二人民医院风湿科,合肥230011

出　　处：《中国基层医药》2023年第7期1116-1120,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：安徽省合肥市“十四五”中医重点专科-中西医结合科项目(合卫中医秘[2021]167号)。

摘　　要：类风湿关节炎(RA)是以侵蚀性关节炎为主要临床特征的一组异质性自身免疫性疾病,其发病机制尚不明确,约70%的患者疾病早期可在血液或滑膜液中检出自身抗体,目前抗环瓜氨酸多肽抗体(ACPA)是临床诊断类风湿关节炎最常用的自身抗体,但ACPA并非RA的特异性抗体,血清ACPA阴性RA生物标志物的发现及临床运用对患者的早期诊断及改善预后有着十分积极的意义。本文就ACPA阴性RA生物标志物相关研究进展进行综述。Rheumatoid arthritis(RA)is a group of heterogeneous autoimmune diseases with erosive arthritis as the main clinical feature.The pathogenesis of RA remains unclear.Autoantibodies can be detected in blood or synovial fluid in approximately 70%of patients with RA in the early stage of the disease.Anti-citrullinated protein antibody(ACPA)is the most commonly used autoantibody in the diagnosis of RA.However,ACPA is not a specific antibody for RA.The discovery and clinical application of serum ACPA-negative RA biomarkers is of positive significance for the early diagnosis and prognosis improvement of RA.This paper reviews the research progress of ACPA-negative RA biomarkers.

关 键 词：关节炎 类风湿 自身免疫疾病 抗环瓜氨酸多肽抗体 生物标记 血清学试验 诊断 综述 

分 类 号：R593.22[医药卫生—内科学]