岩黄连化学成分、药理作用、临床应用研究进展及质量标志物预测分析  

Chemical constituents,pharmacological effects and clinical applications of Corydalis saxicola Bunting and predictive analysis on quality marker

作　　者：曾勇珠 钟华帅 苏晓丹 陆建媚 麦琬婷 黄秋洁 叶勇[1,3] ZENG Yong-zhu;ZHONG Hua-shuai;SU Xiao-dan;LU Jian-mei;MAI Wan-ting;HUANG Qiu-jie;YE Yong(College of Pharmacy,Guangxi Medical University,Nanning 530021,China;College of Pharmacy,Guangxi University of Traditional Chinese Medicine,Nanning 530001,China;Guangxi Key Laboratory of Biological Activity Analysis,Research and Evaluation,Nanning 530021,China)

机构地区：[1]广西医科大学药学院,南宁530021 [2]广西中医药大学药学院,南宁530001 [3]广西生物活性分子研究与评价重点实验室,南宁530021

出　　处：《中国新药杂志》2023年第13期1325-1335,共11页Chinese Journal of New Drugs

基　　金：国家自然科学基金资助项目(81960756,81360689);广西自然科学基金资助项目(2023GXNSFAA026366,2022GXNSFDA035063,2018GXNSFAA050078,2015GXNSFAA139173);广西高校中青年教师科研基础能力提升基金资助项目(2019KY0148,2019KY0315)。

摘　　要：岩黄连(Corydalis saxicola Bunting)主要分布于广西、贵州、云南等地,为广西民间道地药材。岩黄连主要含有生物碱、黄酮、甾体类等化学成分,具有护肝、抗肿瘤、抗氧化等药理作用,常用于治疗疮疖肿毒、肝炎、肝硬化、肝癌等疾病。本文对岩黄连的化学成分和药理作用进行归纳总结,并基于质量标志物(Q-Marker)的核心理念,对岩黄连Q-Marker进行预测分析,为岩黄连质量评价体系的建立提供科学依据及其药用价值开发提供参考。Corydalis saxicola Bunting mainly distributes in Guangxi,Guizhou and Yunnan,etc.,and it is a genuine folk medicine in Guangxi Province.The chemical composition of Corydalis saxicola Bunting mainly contains alkaloids,flavonoids,steroids and so on.It has activities of liver protection,anti-tumor,and anti-oxidation,thus often used in the treatment of sore boils,hepatitis,liver cirrhosis,and liver cancer.The chemical constituents and pharmacological effects of Corydalis saxicola Bunting are summarized in this article,and the quality markers(Q-Marker) of Corydalis saxicola Bunting were predicted and analyzed based on the concept of quality marker,providing scientific basis for the establishment of quality evaluation system of Corydalis saxicola Bunting and reference for the development of its medicinal value.

关 键 词：岩黄连 化学成分 药理作用 临床应用 质量标志物 

分 类 号：R961[医药卫生—药理学]