育龄女性阴道性传播病原体与人乳头瘤病毒及宫颈细胞学异常的相关性分析  

Correlation analysis of vaginal sexually transmitted pathogens with human papilloma virus and cervical cytology abnormalities in women of childbearing age

作　　者：卢宇东 李茂城 黄海勇 陈慕旋 周宏伟[4] 吴显劲 LU Yudong;LI Maocheng;HUANG Haiyong;CHEN Muxuan;ZHOU Hongwei;WU Xianjin(Guangdong Medical University,Zhanjiang 524023,Guangdong,China;Department of Laboratory Medicine,Huizhou First Maternal and Child Health Care Hospital,Huizhou 516000,Guangdong,China;Department of Laboratory Medicine,Huizhou Central People′s Hospital,Huizhou 516000,Guangdong,China;Department of Laboratory Medicine,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,Guangdong,China)

机构地区：[1]广东医科大学,广东湛江524023 [2]惠州市第一妇幼保健院检验科,广东惠州516000 [3]惠州市中心人民医院检验科,广东惠州516000 [4]南方医科大学珠江医院检验医学部,广州510282

出　　处：《中国性科学》2023年第7期46-50,共5页Chinese Journal of Human Sexuality

基　　金：广东省基础与应用基础研究基金(2021B1515230007)。

摘　　要：目的分析育龄女性阴道性传播感染(STIs)病原体与人乳头瘤病毒(HPV)及宫颈细胞学异常的相关性。方法选取2021年1月至10月惠州市中心人民医院妇科就诊的150例育龄女性作为研究对象,根据HPV感染情况分为HPV阳性组(n=58)和HPV阴性组(n=92)。采用聚合酶链反应(PCR)法结合导流杂交法将宫颈脱落细胞标本进行STIs病原体、HPV和子宫细胞学检测。结果在STIs病原体感染中解脲支原体(UU)感染率最高(58.0%),HPV阳性组和HPV阴性组UU、微小脲原体6型(Uup6)和人型支原体(MH)的感染率差异具有统计学意义(χ^(2)=10.110,P=0.001;χ^(2)=12.397,P=0.001;χ^(2)=5.510,P=0.019)。多因素Logistic回归分析显示,HPV阳性组和HPV阴性组Uup6感染率差异具有统计学意义(OR=2.974,95%CI:1.164~7.602,P<0.05)。宫颈细胞学正常组和宫颈细胞学异常组UU和Uup6感染率差异具有统计学意义(χ^(2)=5.622,P=0.018;χ^(2)=5.671,P=0.017),宫颈细胞学正常组和宫颈细胞学异常组HPV合并STIs病原体感染率差异无统计学意义(P>0.05)。结论UU、Uup6和MH是HPV感染的危险因素,Uup6感染是HPV感染的独立危险因素,UU和Uup6感染会增加宫颈病变的风险,但STIs病原体感染不会增加HPV阳性患者宫颈细胞学异常的风险。Objective To analyze the association between pathogens of vaginal sexually transmitted infections(STIs)in women of childbearing age with human papilloma virus(HPV)and cervical cytology abnormalities.Methods From January to October 2021,150 women of childbearing age who visited the Gynecological Department of Huizhou Central People′s Hospital were selected as research projects.The patients were devided into HPV-positive group(n=58)and HPV-negative group(n=92).Their cervical exfoliation cell specimens were tested for STIs pathogens,HPV and uterine cytology by polymerase chain reaction(PCR)combined with diversion hybridization.Results The ureaplasma urealyticum(UU)infection rate was highest(58.0%)among STIs pathogen infections,and the difference in UU,Uup6 and mycoplasma hominis(MH)infection rates between the HPV-positive and negative groups was statistically significant(χ^(2)=10.110,P=0.001;χ^(2)=12.397,P=0.001;χ^(2)=5.510,P=0.019).In the multivariate Logistic regression analysis between STIs pathogens and HPV infection,the difference in Uup6 infection rate between HPV-positive and HPV-negative groups was statistically significant(OR=2.974,95%CI:1.164-7.602,P<0.05).Statistically significant differences in UU,and Uup6 infection rates between normal and abnormal cervical cytology groups(χ^(2)=5.622,P=0.018;χ^(2)=5.671,P=0.017).There was no significant difference in HPV and STIs pathogens infection rates between the normal and abnormal groups of cervical cytology(P>0.05).Conclusions UU,Uup6 and MH infections are risk factors for HPV infection,Uup6 infection is an independent risk factor for HPV infection,UU,Uup and Uup6 infections increase the risk of cervical lesions.However,there is no evidence that STIs pathogen infection increases the risk of cervical cytology abnormalities in HPV-positive patients.

关 键 词：人乳头瘤病毒 解脲支原体 人型支原体 沙眼衣原体 生殖支原体 2型单纯疱疹病毒 

分 类 号：R711[医药卫生—妇产科学]