治疗药物监测中利培酮超警戒浓度典型案例分析  

Typical Cases Analysis of Risperidone Exceeding Alert Concentration in Therapeutic Drug Monitoring

作　　者：朱双燕 王艺[2] 张清盛[2] ZHU Shuangyan;WANG Yi;ZHANG Qingsheng(Leshan People's Hospital,Leshan,Sichuan,China 614000;Zigong Mental Health Center,Zigong,Sichuan,China 643000)

机构地区：[1]四川省乐山市人民医院,四川乐山614000 [2]四川省自贡市精神卫生中心,四川自贡643000

出　　处：《中国药业》2023年第15期123-127,共5页China Pharmaceuticals

摘　　要：目的促进利培酮的临床合理应用。方法采用回顾性分析方法,选取四川省自贡市精神卫生中心2020年1月至2021年12月收治的进行利培酮治疗药物监测(TDM)的住院患者1157例,共监测5454例次TDM,分析其临床资料,选取其中3例利培酮血药浓度超过警戒浓度的典型案例进行分析。结果5454例次监测中,超过警戒浓度(>120 ng/mL)33例次(0.61%)。利培酮可与多种药物和食物相互作用,从而影响血药浓度。TDM能指导医师和药师及时调整用药方案,从而提升患者用药依从性,减少药品不良反应的发生。结论TDM和药师干预能促进利培酮的合理使用。Objective To promote the rational clinical application of risperidone.Methods Retrospective analysis method was adopted,1157 inpatients(5454 monitoring cases)who underwent therapeutic drug monitoring(TDM)of risperidone from January 2020 to December 2021 in the Zigong Mental Health Center were collected to analyze their clinical data,and three typical cases with risperidone concentration exceeding the alert concentration were selected for analysis.Results Among the 5454 monitoring cases,33 cases(0.61%)exceeded the alert concentration(>120 ng/mL).Risperidone could interact with a variety of drugs and foods to affect blood drug concentration.TDM could guide physicians and pharmacists to adjust medication plans in a timely manner,so as to improve medication compliance of patients and reduce the incidence of adverse drug reactions.Conclusion TDM and pharmacists'intervention can promote the rational use of risperidone.

关 键 词：利培酮 治疗药物监测 警戒浓度 典型案例 回顾性分析 

分 类 号：R95[医药卫生—药学] R971.4