溴夫定单药与膦甲酸钠联合泛昔洛韦治疗带状疱疹的疗效和安全性对比研究  

Comparison of Efficacy and Safety of Brivudine Monotherapy and Foscarnet Sodium Combined with Famciclovir in the Treatment of Patients with Herpes Zoster

作　　者：陈韬宇 苏东强 纪砚奇 张峰[1,2] CHEN Taoyu;SU Dongqiang;JI Yanqi;ZHANG Feng(Dept.of Dermatology,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;Dept.of Dermatology,the Sixth Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院皮肤科,哈尔滨150001 [2]哈尔滨医科大学附属第六医院皮肤科,哈尔滨150001

出　　处：《中国医院用药评价与分析》2023年第7期776-779,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：黑龙江省自然科学基金项目(No.LH2021H054);湖北陈孝平科技发展基金项目(No.CXPJJH122003-34)。

摘　　要：目的:比较溴夫定单药与膦甲酸钠联合泛昔洛韦治疗带状疱疹的疗效和安全性。方法:采用回顾性研究方法,选取2020年7月至2021年12月于哈尔滨医科大学附属第一医院皮肤科就诊的接受口服溴夫定片(溴夫定组,100例)或静脉滴注膦甲酸钠氯化钠注射液联合口服泛昔洛韦片(膦甲酸钠联合泛昔洛韦组,100例)治疗满1周的带状疱疹患者200例。收集患者基本信息、疗效评价参数(包括止疱时间、结痂时间、脱痂时间、疼痛减轻50%时间)、带状疱疹后神经痛发病情况和药品不良反应,并比较两组患者临床疗效和不良反应发生率的差异。结果:两组患者止疱时间、结痂时间、脱痂时间的差异均无统计学意义(P>0.05);溴夫定组患者疼痛减轻50%时间显著短于膦甲酸钠联合泛昔洛韦组,带状疱疹后神经痛发生率显著低于膦甲酸钠联合泛昔洛韦组,差异均有统计学意义(P<0.05)。溴夫定组、膦甲酸钠联合泛昔洛韦组患者的总有效率分别为86%(86/100)、82%(82/100),差异无统计学意义(P>0.05)。溴夫定组患者的不良反应发生率显著低于膦甲酸钠联合泛昔洛韦组,差异有统计学意义(P<0.05)。结论:口服溴夫定片与静脉滴注膦甲酸钠氯化钠注射液联合口服泛昔洛韦片治疗带状疱疹的疗效相当,但溴夫定缓解带状疱疹急性期疼痛、后遗神经痛效果更佳,而且口服用药方便,安全性更好。OBJECTIVE:To probe into the efficacy and safety of brivudine monotherapy and foscarnet sodium combined with famciclovir in the treatment of patients with herpes zoster.METHODS:Retrospective study was conducted.A total of 200 patients with herpes zoster treated with oral brivudine tablets(brovudine group,100 cases)or intravenous drip of foscarnet sodium and sodium chloride injection combined with oral famciclovir tablets(foscarnet sodium combined with famciclovir group,100 cases)for more than 1 week were extracted from the dermatology department of the First Affiliated Hospital of Harbin Medical University from Jul.2020 to Dec.2021.General information of patients,the parameters of efficacy evaluation(such as stopping time of blister,scab time,removal time of scab and relief time of 50%pain),incidence of postherpetic neuralgia and adverse drug reactions were collected.The clinical efficacy and incidence of adverse drug reactions were compared between two groups.RESULTS:There were no significant differences in the stopping time of blister,time to scab and removal time of scab between two groups(P>0.05).The relief time of 50%pain in brovudine group was significantly shorter than that in foscarnet sodium combined with famciclovir group,and incidence of postherpetic neuralgia was significantly lower than that in the foscarnet sodium combined with famciclovir group,with statistically significant differences(P<0.05).The total effective rate was 86%(86/100)in the brovudine group and 82%(82/100)in the foscarnet sodium combined with famciclovir group,with no statistically significant difference(P>0.05).The incidence of adverse drug reactions in brovudine group was significantly lower than that in foscarnet sodium combined with famciclovir group,the difference was statistically significant(P<0.05).CONCLUSIONS:The efficacy of oral brivudine tablets and intravenous drip of foscarnet sodium and sodium chloride injection combined with oral famciclovir tablets is comparable in the treatment of herpes zoster,yet bromovudine is mor

关 键 词：带状疱疹 溴夫定 膦甲酸钠 泛昔洛韦 带状疱疹后神经痛 

分 类 号：R978.7[医药卫生—药品]