清热泄浊方联合尿毒清颗粒对痛风性肾病合并肾衰竭患者肾纤维化及微炎症状态的影响  

Effects of Heat-Clearing and Turbidity-Expelling Formula Combined with Niaoduqing Granules on Renal Fibrosis and Micro-Inflammation State in Patients with Gouty Nephropathy Complicated with Renal Failure

作　　者：刘赫 潘红梅[1,2] 赵春燕[1] 李莹 马金荣 李莉[2] LIU He;PAN Hongmei;ZHAO Chunyan;LI Ying;MA Jinrong;LI Li(Graduate School,Hebei University of Traditional Chinese Medicine,Shijiazhuang 050091,China;Dept.of Nephroma,Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Hebei Cangzhou 061000,China)

机构地区：[1]河北中医学院研究生院,石家庄050091 [2]河北省沧州中西医结合医院肾病科,河北沧州061000

出　　处：《中国医院用药评价与分析》2023年第7期796-799,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：河北省中医药管理局项目(No.2022265)。

摘　　要：目的:探讨清热泄浊方联合尿毒清颗粒对痛风性肾病合并肾衰竭患者肾纤维化及微炎症状态的影响。方法:纳入2020年9月至2022年9月于该院就诊的痛风性肾病合并肾衰竭患者80例,采用随机数字表法分为观察组和对照组,各40例。两组患者均予以常规治疗,对照组患者采用尿毒清颗粒治疗,观察组患者采用清热泄浊方联合尿毒清颗粒治疗。比较两组患者的临床疗效及安全性,观察两组患者治疗前后肾功能指标[血尿酸(UA)、尿素氮(BUN)、肌酐(SCr)和24 h尿蛋白定量(24 h UTP)]、肾纤维化指标[血清胱抑素(Cys C)、血清透明质酸(HA)]及微炎症状态指标[红细胞沉降率(ESR)、C反应蛋白(CRP)、白细胞介素6(IL-6)和白细胞介素1β(IL-1β)]水平的变化。结果:观察组患者的总有效率为92.50%(37/40),与对照组(75.00%,30/40)比较明显升高,差异有统计学意义(P<0.05)。治疗后,观察组患者的UA、SCr、BUN和24 h UTP水平与对照组比较均明显降低,差异均有统计学意义(P<0.05)。治疗后,观察组患者血清Cys C、HA含量与对照组比较明显降低,差异均有统计学意义(P<0.05)。治疗后,观察组患者血清CRP、IL-6及IL-1β水平与对照组比较明显降低,差异均有统计学意义(P<0.05)。观察组、对照组患者的不良反应发生率分别为10.00%(4/40)、7.50%(3/40),差异无统计学意义(P>0.05)。结论:清热泄浊方与尿毒清颗粒联合应用能减轻痛风性肾病合并肾衰竭患者肾纤维化及微炎症状态,改善肾功能,效果显著,且具有良好的安全性。OBJECTIVE:To probe into the effects of heat-clearing and turbidity-expelling formula combined with Niaoduqing granules on renal fibrosis and micro-inflammation in patients with gouty nephropathy complicated with renal failure.METHODS:A total of 80 patients with gouty nephropathy complicated with renal failure admitted into the hospital from Sept.2020 to Sept.2022 were enrolled and divided into observation group and control group via the random number table method,with 40 cases in each group.Both groups was given conventional therapy,the control group was treated with Niaoduqing granules,the observation group was given heat-clearing and turbidity-expelling prescription combined with Niaoduqing granules.The clinical efficacy and safety were compared between two groups,the indicators of renal function[blood uric acid(UA),urea nitrogen(BUN),creatinine(SCr)and 24 h urine protein quantitation(24 h UTP)],renal fibrosis[serum cystatin(Cys C)and serum hyaluronic acid(HA)]and microinflammatory state[erythrocyte sedimentation rate(ESR),C reaction protein(CRP),interleukin 6(IL-6)and interleukin IL-1β(IL-1β)]were observed before and after treatment.RESULTS:The total effective rate of the observation group was 92.50%(37/40),significantly higher than that of the control group(75.00%,30/40),with statistically significant difference(P<0.05).After treatment,the UA,SCr,BUN and 24 h UTP levels in the observation group were significantly lower than those in the control group,with statistically significant difference(P<0.05).After treatment,the serum Cys C and HA contents in the observation group were significantly lower than those in the control group,with statistically significant difference(P<0.05).After treatment,the serum CRP,IL-6 and IL-1βlevels in the observation group were significantly lower than those in the control group,with statistically significant difference(P<0.05).The incidences of adverse drug reactions in the observation group and the control group were 10.00%(4/40)and 7.50%(3/40),respectively,the difference has

关 键 词：清热泄浊方 尿毒清颗粒 痛风性肾病 肾衰竭 肾纤维化 微炎症状态 

分 类 号：R932[医药卫生—生药学]