小儿喘咳液治疗小儿呼吸道合胞病毒肺炎的临床研究  

Clinical Research on Xiao’er Kechuan Liquid in the Treatment of Respiratory Syncytial Virus Pneumonia in Children

作　　者：张春红 张莹[1] 梁俊杰 ZHANG Chunhong;ZHANG Ying;LIANG Junjie(Dept.of Pediatrics,the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510410,China)

机构地区：[1]广州中医药大学第一附属医院儿科,广州510410

出　　处：《中国医院用药评价与分析》2023年第7期824-827,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:观察小儿喘咳液治疗呼吸道合胞病毒肺炎患儿的临床疗效,探讨其对患儿炎症因子、免疫功能的影响。方法:选取2019年9月至2021年9月该院儿科病房收治的呼吸道合胞病毒肺炎患儿80例,按随机数字表法分为对照组和观察组,每组40例。对照组患儿采用常规治疗方法,观察组患儿在对照组的基础上口服小儿喘咳液,两组患儿均给药7 d。观察并对比两组患儿的临床疗效,治疗前后的免疫功能相关指标和炎症因子[白细胞介素(IL)6、IL-8和降钙素原(PCT)]水平变化。结果:观察组患儿的总有效率为97.5%(39/40),明显高于对照组的82.5%(33/40),差异有统计学意义(P<0.05)。观察组患儿发热、咳嗽和喘息消失时间均短于对照组,差异有统计学意义(P<0.05)。观察组患儿治疗后血清CD3^(+)、CD4^(+)水平较对照组明显升高,CD8^(+)水平较对照组明显降低,差异均有统计学意义(P<0.05);观察组患儿治疗后炎症因子(IL-6、IL-8和PCT)水平明显降低,与对照组相比,差异有统计学意义(P<0.05)。结论:小儿喘咳液治疗呼吸道合胞病毒肺炎,可增强患儿的免疫功能,降低炎症反应,改善临床症状。OBJECTIVE:To observe the clinical efficacy of Xiao’er Kechuan liquid in the treatment of respiratory syncytial virus pneumonia in children,so as to probe into its effects on inflammatory factors and immune function levels in children.METHODS:A total of 80 children with respiratory syncytial virus pneumonia admitted into the pediatric ward of the hospital from Sept.2019 to Sept.2021 were extracted to be divided into the control group and observation group using a random number table method,with 40 cases in each group.The control group was given conventional treatment,whiled the observation group was given Xiao’er Kechuan liquid orally on the basis of the control group,both group were administrated for 7 days.The clinical efficacy,changes of immune function related indicators and inflammatory factors[interleukin(IL)-6,IL-8,procalcitonin(PCT)]levels were observed and compared between two group before and after treatments.RESULTS:The total effective rate of the observation group was 97.5%(39/40),significantly higher than that of the control group(82.5%,33/40),with statistically significant difference(P<0.05).The disappearance time of fever,cough and wheezing in the observation group were shorter than those in the control group,with statistically significant difference(P<0.05).After treatment,the serum CD3^(+)and CD4^(+)levels in the observation group were significantly higher than those in the control group,while the CD8^(+)level was significantly lower than that in the control group,with statistically significant differences(P<0.05);the inflammatory factors(IL-6,IL-8,PCT)levels in the observation group were significantly decreased after treatment,and the difference was statistically significant compared with those in the control group(P<0.05).CONCLUSIONS:Xiao’er Kechuan liquid for the treatment of respiratory syncytial virus pneumonia can enhance the immunity of children,reduce inflammation reaction and improve clinical symptoms.

关 键 词：小儿喘咳液 呼吸道合胞病毒肺炎 临床疗效 炎症因子 

分 类 号：R932[医药卫生—生药学]