中医药防治特发性肺纤维化表观遗传修饰研究现状  

Research Status of TCM in Prevention and Treatment of Idiopathic Pulmonary Fibrosis Based on Epigenetic Modification

作　　者：焦蕊[1] 刘勇明[1] 姜会来 王天娇 吕晓东[2] 马丽佳[1] 杨丽[1] JIAO Rui;LIU Yongming;JIANG Huilai;WANG Tianjiao;LYU Xiaodong;MA Lijia;YANG Li(Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China;Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China)

机构地区：[1]辽宁中医药大学附属医院,辽宁沈阳110032 [2]辽宁中医药大学,辽宁沈阳110847

出　　处：《辽宁中医药大学学报》2023年第6期96-100,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：辽宁省中医药特色人才培养项目(辽中医药综合字[2021]38号);辽宁省科学技术计划项目(2019-ZD-0962)。

摘　　要：特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是严重危害我国居民健康的呼吸系统疾病之一,发病机制复杂且缺乏理想治疗药物,已成为重大公共卫生问题。IPF发生发展过程中表观遗传修饰得到了广泛的关注,新近越来越多研究证实特定基因甲基化、组蛋白乙酰化和微小RNA(miRNA)差异性表达均可能作为IPF的信号分子,在疾病诊断、病情严重程度评估和治疗方面发挥不可预估的作用,以此阐述IPF发病机制具有重要意义。中医药治疗IPF历史悠久,具有整体调节的独特优势,且安全性较高,目前临床上使用中医药治疗IPF已然成为发展趋势。新近研究发现中药复方和单体成分通过表观遗传修饰发挥抗纤维化作用。该文拟对表观遗传修饰在IPF发生发展中的作用机制以及中医药通过调控表观遗传防治IPF作用进行综述,以期为中医药现代化研究更好指导IPF临床实践提供思路。Idiopathic pulmonary fibrosis(IPF)is one of the respiratory diseases that seriously endanger the health of Chinese residents.Its pathogenesis is complex and clinically ideal therapeutic drugs are still lacking for treatment of IPF.It has become a major public health problem.During the development of IPF,epigenetic modification has received extensive attention.Recently,more and more studies have confirmed that methylation of specific genes,histone acetylation and differential expression of miRNAs may all act as signal molecules of IPF and play an unpredictable role in disease diagnosis,disease severity assessment and treatment.It is of great significance to explain the pathogenesis of IPF.The treatment of IPF with traditional Chinese medicine(TCM)has a long history,with unique efficacy and obvious advantages of overall regulation,and high safety.At present,the clinical use of TCM to treat IPF has become a development trend.Recent studies have found that Chinese herbal compounds and monomer components play an anti fibrosis role through epigenetic modification.This paper reviews the mechanism of epigenetic modification in occurrence and development of IPF and the role of TCM in prevention and treatment of IPF by regulating epigenetic modification,in order to provide ideas for the modernization of TCM to better guide the clinical practice of IPF.

关 键 词：特发性肺纤维化 表观遗传修饰 中医药 DNA甲基化 组蛋白修饰 微小RNA 

分 类 号：R563[医药卫生—呼吸系统]