“化瘀解毒”法防治冠状动脉介入术后患者造影剂肾病临床疗效研究  

Clinical Study on the Prevention and Treatment of Contrast Nephropathy in Patients after PCI with the Method of“Removing Blood Stasis and Detoxifying”

作　　者：于开锋[1,2] 张静生[2] 杨关林[1] YU Kaifeng;ZHANG Jingsheng;YANG Guanlin(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医药大学学报》2023年第6期127-131,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：辽宁省自然科学基金指导计划项目(2019-ZD-0944)。

摘　　要：目的 观察“化瘀解毒”法对经皮冠状动脉介入术后造影剂肾病的预防效果,探讨“化瘀解毒”法预防造影剂肾病的临床疗效及安全性。方法 纳入2019年10月-2021年3月期间于辽宁中医药大学附属医院心内科住院诊断为冠心病(血瘀证)并拟行经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)的住院患者,按1∶1比例随机分为中药干预组和对照组。中药干预组于术前0~6 h、术后6~12 h静脉应用肾康注射液各1次(2次用药间隔12 h),两组其他干预措施完全相同。两组病人分别于术前、术后72 h和1周测定血清肌酐、尿素氮等指标,部分患者于术前、术后72 h、术后1周行肾损伤尿系列检测(免疫球蛋白G、β2-微球蛋白、α1-微球蛋白、尿肌酐、N-乙酰-β-D氨基葡萄糖苷酶),以评价肾小球滤过功能及肾脏损害程度等。结果 术后72 h、术后1周中药干预组血清肌酐(Scr)、血尿素氮(BUN)、免疫球蛋白G、β2-微球蛋白、α1-微球蛋白、尿肌酐、N-乙酰-β-D氨基葡萄糖苷酶值明显低于对照组(P<0.05)。术后72 h、术后1周中药干预组肾小球滤过率较对照组明显升高(P<0.05)。结论 肾康注射液可以降低患者PCI术后Scr、BUN、免疫球蛋白G、β2-微球蛋白、α1-微球蛋白、尿肌酐、N-乙酰-β-D氨基葡萄糖苷酶水平,提高肾小球滤过率,起到保护肾功能的作用,且临床用药安全。Objective To observe the preventive effect of“removing blood stasis and detoxifying”method on contrast nephropathy after percutaneous coronary intervention(PCI),and to explore the clinical efficacy and safety of“removing blood stasis and detoxifying”method in preventing contrast nephropathy.Methods From October 2019 to March 2021,the hospitalized patients who were diagnosed with coronary heart disease(blood stasis syndrome)in the department of cardiology of the affiliated hospital of Liaoning university of traditional Chinese medicine and planned to undergo PCI treatment were randomly divided into Chinese medicine intervention group and control group according to the ratio of 1∶1.Shenkang Injection(肾康注射液)was administered intravenously in the Chinese medicine intervention group at 0-6 h before operation and 6-12 h after operation(the interval between two injections was 12 h).Other intervention measures in the two groups were completely the same.Serum creatinine(Scr),urea nitrogen(BUN)and other indicators were measured in the two groups of patients before operation,72 hours after operation and 1 week after operation.Some patients were measured before operation,72 hours after operation and 1 week after operation for renal injury urine(immunoglobulin G,β2-microglobulin,α1-microglobulin,urinary creatinine,N-acetyl-β-D glucosaminidase)and glomerular filtration rate to evaluate the glomerular filtration function and the degree of renal damage.Results Scr,BUN,immunoglobulin G,β2-microglobulin,α1-microglobulin,urinary creatinine,N-acetyl-β-D glucosaminidase value was significantly lower than that of the control group(P<0.05).The glomerular filtration rate of the Chinese medicine intervention group was significantly higher than that of the control group at 72 hours and 1 week after operation(P<0.05).Conclusion Shenkang Injection can reduce Scr,BUN,immunoglobulin G,β2-microglobulin,α1-microglobulin,urinary creatinine,N-acetyl-β-D glucosaminidase level,improve glomerular filtration rate,play a ro

关 键 词：化瘀解毒法 PCI术 造影剂肾病 疗效研究 

分 类 号：R692[医药卫生—泌尿科学]