检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:徐丽文 杨康 孙亚男[1] 楚冬海[2] 李峰[1] 张振秋[1] XU Liwen;YANG Kang;SUN Yanan;CHU Donghai;LI Feng;ZHANG Zhenqiu(Liaoning University of Traditional Chinese Medicine,Dalian 116600,Liaoning,China;Liaoning University of Science and Technology,Benxi 117004,Liaoning,China)
机构地区:[1]辽宁中医药大学,辽宁大连116600 [2]辽宁科技学院,辽宁本溪117004
出 处:《中华中医药学刊》2023年第7期251-254,共4页Chinese Archives of Traditional Chinese Medicine
基 金:辽宁省博士科研基金项目(2021-BS-252)。
摘 要:研究乌头注射液对大鼠体内肝肾功能的影响,进一步探讨乌头注射液对大鼠肝肾毒性作用。方法 将18只大鼠随机分为3组,即空白组(A),单次给药组(B)和连续7 d多次给药组(C),每组6只。适应性喂养1周后,单次给药组(0.65 mg/kg)肌肉注射1 d, 1次/d,连续多次给药组(0.65 mg/kg)肌肉注射7 d, 1次/d,两组于末次给药后禁食12 h,收集尿液,解剖取血,取完整肝脏及肾脏,称取肝脏、肾脏湿重,计算肝脏指数和肾脏指数,检测大鼠血清和尿液中肝肾功能指标。结果 大鼠肾脏指数、总超氧化物歧化酶(SOD)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、甲胎蛋白(AFP)、丙二醛(MDA)、血肌酐(CRE)、总蛋白(TP)、胱抑素C(Cys-C)、总胆汁酸(TBA)、α1-微球蛋白(α1-MG)、β2-微球蛋白(β2-MG)生化指标差异具有统计学意义(P<0.05)。结论 乌头注射液对于肝肾功能有影响,长期使用可能对肝肾产生毒性。Objective To study the effect of Wutou Injection(乌头注射液)on liver and kidney function and further investigate the toxicity effect of liver and kidney in rats.Methods Eighteen rats were randomly divided into 3 groups,namely,blank group(A),single dose group(B)and seven consecutive days of multiple dose group(C),with 6 mice in each group.One week after adaptive feeding,a single administration group(0.65 mg/kg)was given the muscle injection for 1 d,once a day.The continuous administration group(0.65 mg/kg)was given the muscle injection for 7 d,once a day.The two groups fasted for 12 h after the last administration.The urine was collected and the blood was taken out.The liver and kidney were completely taken out.The wet weights of liver and kidney were weighed,liver index and kidney index wer calculated and the liver and kidney function index in serum and urine of the rats were tested.Results The rat kidney index,total superoxide dismutase(SOD),alanine aminotransferase(ALT),aspartate aminotransferase(AST),alpha fetoprotein(AFP),malondialdehyde(MDA),serum creatinine(CRE),total protein(TP),cystatin C(Cys-C),total bile acid(TBA),α1-microglobulin(α1-MG)andβ2-microglobulin(β2-MG)showed significant differences(P<0.05).Conclusion Wutou Injection has an effect on liver and kidney function,and long-term use may cause toxicity to liver and kidney.
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:3.23.102.227