高迁移率族蛋白B1在炎症诱导早期自然流产中的病理机制研究  

Study on pathological mechanism of high mobility group protein B1 in early spontaneous abortion induced by inflammation

作　　者：冯家成 陈咏梅 黄源平 陈海玲[1] FENG Jiacheng;CHEN Yongmei;HUANG Yuanping;CHEN Hailing(Department of Pathology,Zhuhai Center For Maternal and Child Health Care;Department of Obstetrics,Zhuhai Center For Maternal and Child Health Care,Zhuhai,519000,Guangdong,China)

机构地区：[1]珠海市妇幼保健院病理科 [2]珠海市妇幼保健院产科,广东珠海519000

出　　处：《大医生》2023年第15期8-11,共4页Doctor

基　　金：珠海市科技计划项目(编号:ZH22036201210164PWC)。

摘　　要：目的 探讨高迁移率族蛋白B1(HMGB1)表达在炎症因子诱导发生早期流产中的病理机制,为临床提供参考。方法 选取2021年8月至2022年12月珠海市妇幼保健院收治的40例早期自然流产者作为研究组,另选取珠海市妇幼保健院同期40例选择手术终止妊娠者为对照组进行回顾性分析。采集两组研究对象的胎盘组织,比较两组研究对象胎盘组织中肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)水平及HMGB1表达情况,分析血清TNF-α、IL-1及IL-6与HMGB1表达的相关性。结果 研究组研究对象胎盘组织TNF-α、IL-1、IL-6水平及HMGB1表达水平高于对照组(P<0.05)。研究组研究对象人绒毛组织块中TNF-α、IL-1及IL-6水平高于对照组(P<0.05)。研究组研究对象人绒毛滋养细胞平均每cm2血管形成数量多于对照组(P<0.05)。相关性分析显示TNF-α、IL-1及IL-6水平与HMGB1表达呈正相关(P<0.05)。结论 早期自然流产者的机体炎症因子及HMGB1表达水平较高,且与HMGB1表达呈正相关,属于早期自然流产的重要病理基础。Objective To explore the pathological mechanism of high mobility group protein B1(HMGB1)expression in early spontaneous abortion induced by inflammatory factors,and to provide clinical reference.Methods 40 cases of early spontaneous abortion admitted to Zhuhai Center For Maternal and Child Health Care from August 2021 to December 2022 were selected as the study group,and 40 cases of surgical termination of pregnancy were selected as the control group for retrospective analysis.The placental tissues of the two groups were collected,and the expressions of tumor necrosis factor-α(TNF-α),interleukin-1(IL-1),interleukin-6(IL-6)and HMGB1 in the placental tissues of the two groups were compared,and the correlation between TNF-α,IL-1,IL-6 and HMGB1 expression was analyzed.Results The levels of TNF-α,IL-1,IL-6 and HMGB1 in placental tissues of the study group were higher than those in the control group(P<0.05).The levels of TNF-α,IL-1 and IL-6 in human villus tissue blocks in the study group were higher than those in the control group(P<0.05).The average number of blood vessel formation per cm2 in human villus tissue blocks in the study group was higher than that in the control group(P<0.05).Correlation analysis showed a positive correlation of TNF-α,IL-1 and IL-6 levels with HMGB1 expression(P<0.05).Conclusion The expression levels of inflammatory factors and HMGB1 in early spontaneous abortion are higher,and are positively correlated with the expression of HMGB1,which is an important pathological basis of early spontaneous abortion.

关 键 词：高迁移率族蛋白B1 炎症因子 早期自然流产 相关性 

分 类 号：R714.21[医药卫生—妇产科学]