《医方类聚·诸风门》治疗头痛方剂的用药规律分析  

Analysis of the Medication Rules of Headache Prescription in Yifang Leiju·Zhufengmen

作　　者：李代均 王新志[2] LI Daijun;WANG Xinzhi(Henan University of Chinese Medicine,Zhengzhou Henan 450046,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou Henan 450000,China)

机构地区：[1]河南中医药大学,河南郑州450046 [2]河南中医药大学第一附属医院,河南郑州450000

出　　处：《中医药导报》2023年第7期7-12,共6页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家中医药管理局中医药领军人才支持计划(国中医药人教发〔2018〕284号);全国名老中医药专家王新志传承工作室建设项目(豫中医科教〔2017〕5号)。

摘　　要：目的:挖掘朝鲜王朝古籍《医方类聚·诸风门》中治疗头痛的处方用药规律。方法:收集《医方类聚·诸风门》中治疗头痛的内服方剂,将符合纳入标准的处方录入中医传承辅助平台(V2.5)软件构建数据库,基于关联规则和熵聚类等方法分析其方剂的用药频数、性味归经、组方规律、药物核心组合、新方组合等。结果:共纳入100首方剂,涉及中药131味,用药频数≥14的中药21味,药性以温、寒为主,药味以辛、甘、苦为主,归肺、肝、脾经中药最多,常用药物组合20个,药物组合关联规则18条,关联系数≥0.023的药对31个,核心药物组合28个,新方组合9个。结论:《医方类聚·诸风门》反映了中国明代以前医家治疗头痛时重视使用川芎和防风,以祛风止痛为核心治法,辅以解表散风、平抑肝阳、燥湿化痰之法,强调肺、肝、脾三经在辨治头痛中的地位,并辅助使用芳香开窍药和虫类药,可为现代临床诊疗头痛提供参考。Objective:To explore the prescription rules of headache in the ancient books of Yifang Leiju·Zhufengmen.Methods:The internal prescriptions for the treatment of headache in Yifang Leiju·Zhufengmen were collected,and the prescriptions that met the inclusion criteria were entered into the traditional Chinese medicine inheritance support platform(V2.5)software to construct a database.Based on association rules and entropy clustering,the frequency of medication,taste and meridian tropism,prescription rules,drug core combinations,and new prescription combinations were analyzed.Results:A total of 100 prescriptions were included,involving 131 flavors of traditional Chinese medicine,21 flavors of traditional Chinese medicine with frequency greater than 14.The medicinal properties were mainly warm and cold,and the flavors were mainly pungent,sweet and bitter.The lung,liver and spleen meridians were the most.There were 20 commonly used drug combinations,18 drug combination association rules,31 drug pairs with correlation coefficient greater than 0.023,28 core drug combinations and 9 new prescription combinations.Conclusion:Yifang Leiju·Zhufengmen reflects that doctors before the Ming Dynasty in China paid attention to the use of Chuanxiong(Chuanxiong Rhizoma)and Fangfeng(Saposhnikoviae Radix)in the treatment of headache,with dispelling wind and relieving pain as the core treatment,supplemented by the methods of relieving exterior and dispelling wind,calming liver yang,drying dampness and resolving phlegm,emphasizing the position of the three meridians of lung,liver and spleen in the treatment of headache,and assisting the use of aromatic resuscitation drugs and insect drugs,which can provide a reference for modern clinical treatment of headache.

关 键 词：头痛 《医方类聚》 用药规律 朝鲜王朝 中医传承辅助平台 数据挖掘 

分 类 号：R2-52[医药卫生—中医学]