胺碘酮联合美托洛尔治疗冠心病心律失常的临床效果研究  

Study on clinical effect of amiodarone combined with metoprolol in the treatment of arrhythmias in coronary heart disease

作　　者：张爱兰 李平 ZHANG Ai-lan;LI Ping(Dongcheng Hospital,Dongying 257091,China)

机构地区：[1]山东省东营市东城医院,257091 [2]山东省东营市第二人民医院,257300

出　　处：《中国实用医药》2023年第14期12-15,共4页China Practical Medicine

摘　　要：目的探讨胺碘酮联合美托洛尔治疗冠心病心律失常的临床效果。方法88例冠心病心律失常患者,以随机数字表法分为A组和B组,每组44例。A组使用胺碘酮治疗,B组使用胺碘酮联合美托洛尔治疗。比较两组临床效果,治疗前后心绞痛相关指标、心功能指标[左室射血分数(LVEF)、心率(HR)、左室舒张末期内径(LVEDD)],生活质量评分。结果B组治疗总有效率97.73%高于A组的84.09%,差异有统计学意义(P<0.05)。治疗后,B组心绞痛发作次数(2.05±1.08)次/周少于A组的(3.22±1.24)次/周,发作间隔时间(5.13±1.34)d长于A组的(3.33±1.23)d,发作持续时间(5.25±2.13)min短于A组的(7.85±2.77)min,差异均有统计学意义(P<0.05)。治疗后,B组LVEF(42.87±9.36)%高于A组的(37.01±8.27)%,HR(75.00±13.00)次/min慢于A组的(95.00±12.00)次/min,LVEDD(55.57±7.21)mm小于A组的(62.63±8.03)mm,差异均有统计学意义(P<0.05)。B组精神健康、生理功能、社会功能、情感职能、躯体疼痛评分分别为(82.88±6.71)、(70.52±9.28)、(66.84±9.43)、(73.19±6.68)、(78.68±5.91)分,均高于A组的(70.52±3.23)、(62.15±7.10)、(52.02±6.13)、(60.58±4.31)、(68.85±6.88)分,差异有统计学意义(P<0.05)。结论胺碘酮联合美托洛尔治疗冠心病心律失常不仅能够提高治疗效果,还能减少心律失常发作次数,缩短发作持续时间,值得在临床治疗中普及与推广。Objective To discuss the clinical effect of amiodarone combined with metoprolol in the treatment of arrhythmias in coronary heart disease.Methods A total of 88 patients with arrhythmia in coronary heart disease were randomly divided into group A and group B,with 44 cases in each group.Group A was treated with amiodarone,and group B with amiodarone and metoprolol.Both groups were compared in terms of clinical effects,angina pectoric-related indexes,cardiac function indexes[left ventricular ejection fraction(LVEF),heart rate(HR),left ventricular end-diastolic diameter(LVEDD)]and quality of life scores before and after treatment.Results The total effective rate of treatment of 97.73%in group B was higher than that of 84.09%in group A,and the difference was statistically significant(P<0.05).After treatment,the frequency of angina attacks of(2.05±1.08)attacks per week in group B was less than that of(3.22±1.24)attacks per week in group A;the interval between attacks of(5.13±1.34)d in group B was longer than of(3.33±1.23)d in group A;the duration of attacks of(5.25±2.13)min in group B shorter than that of(7.85±2.77)min in group A;the differences were all statistically significant(P<0.05).After treatment,LVEF of(42.87±9.36)%in group B was higher than that of(37.01±8.27)%in group A;HR of(97.00±13.00)beats/min in group B was slower than that of(95.00±12.00)beats/min in group A;LVEDD of(55.57±7.21)mm in group B was smaller than that of(62.63±8.03)mm in group A;all differences were statistically significant(P<0.05).The scores of mental health,physiological function,social function,emotional function and physical pain were(82.88±6.71),(70.52±9.28),(66.84±9.43),(73.19±6.68)and(78.68±5.91)points in group B,which were higher than those of(70.52±3.23),(62.15±7.10),(52.02±6.13),(60.58±4.31)and(68.85±6.88)points in group A,and the differences were statistically significant(P<0.05).Conclusion Amiodarone combined with metoprolol in the treatment of arrhythmia in coronary heart disease can not only improve the t

关 键 词：胺碘酮 美托洛尔 冠心病 心律失常 发作次数 持续时间 

分 类 号：R541[医药卫生—心血管疾病]